Please use this identifier to cite or link to this item: https://doi.org/10.1038/msb.2011.80
Title: Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae
Authors: Zhang, J 
Vaga, S
Chumnanpuen, P
Kumar, R
Vemuri, G.N
Aebersold, R
Nielsen, J
Keywords: amino acid
glutamate dehydrogenase
mammalian target of rapamycin complex 1
nicotinamide adenine dinucleotide phosphate
phosphotransferase
Snf1 kinase
unclassified drug
fatty acid
protein serine threonine kinase
rapamycin
Saccharomyces cerevisiae protein
SNF1 related protein kinases
SNF1-related protein kinases
TORC1 protein complex, S cerevisiae
transcription factor
transcriptome
article
biosynthesis
chemostat
fatty acid metabolism
fatty acid oxidation
metabolic regulation
nonhuman
peroxisome
priority journal
Saccharomyces cerevisiae
upregulation
cytology
gene expression regulation
genetics
metabolism
methodology
systems biology
Saccharomyces cerevisiae
Saccharomyces cerevisiae
Amino Acids
Fatty Acids
Gene Expression Regulation, Fungal
Glutamate Dehydrogenase
Protein-Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sirolimus
Systems Biology
Transcription Factors
Transcriptome
Issue Date: 2011
Publisher: EMBO Press
Citation: Zhang, J, Vaga, S, Chumnanpuen, P, Kumar, R, Vemuri, G.N, Aebersold, R, Nielsen, J (2011). Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae. Molecular Systems Biology 7 : 545. ScholarBank@NUS Repository. https://doi.org/10.1038/msb.2011.80
Rights: Attribution 4.0 International
Abstract: Nutrient sensing and coordination of metabolic pathways are crucial functions for all living cells, but details of the coordination under different environmental conditions remain elusive. We therefore undertook a systems biology approach to investigate the interactions between the Snf1 and the target of rapamycin complex 1 (TORC1) in Saccharomyces cerevisiae. We show that Snf1 regulates a much broader range of biological processes compared with TORC1 under both glucose-and ammonium-limited conditions. We also find that Snf1 has a role in upregulating the NADP +-dependent glutamate dehydrogenase (encoded by GDH3) under derepressing condition, and therefore may also have a role in ammonium assimilation and amino-acid biosynthesis, which can be considered as a convergence of Snf1 and TORC1 pathways. In addition to the accepted role of Snf1 in regulating fatty acid (FA) metabolism, we show that TORC1 also regulates FA metabolism, likely through modulating the peroxisome and Î 2-oxidation. Finally, we conclude that direct interactions between Snf1 and TORC1 pathways are unlikely under nutrient-limited conditions and propose that TORC1 is repressed in a manner that is independent of Snf1. © 2011 EMBO and Macmillan Publishers Limited All rights reserved.
Source Title: Molecular Systems Biology
URI: https://scholarbank.nus.edu.sg/handle/10635/178167
ISSN: 1744-4292
DOI: 10.1038/msb.2011.80
Rights: Attribution 4.0 International
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