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https://doi.org/10.1038/msb.2011.80
Title: | Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae | Authors: | Zhang, J Vaga, S Chumnanpuen, P Kumar, R Vemuri, G.N Aebersold, R Nielsen, J |
Keywords: | amino acid glutamate dehydrogenase mammalian target of rapamycin complex 1 nicotinamide adenine dinucleotide phosphate phosphotransferase Snf1 kinase unclassified drug fatty acid protein serine threonine kinase rapamycin Saccharomyces cerevisiae protein SNF1 related protein kinases SNF1-related protein kinases TORC1 protein complex, S cerevisiae transcription factor transcriptome article biosynthesis chemostat fatty acid metabolism fatty acid oxidation metabolic regulation nonhuman peroxisome priority journal Saccharomyces cerevisiae upregulation cytology gene expression regulation genetics metabolism methodology systems biology Saccharomyces cerevisiae Saccharomyces cerevisiae Amino Acids Fatty Acids Gene Expression Regulation, Fungal Glutamate Dehydrogenase Protein-Serine-Threonine Kinases Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Sirolimus Systems Biology Transcription Factors Transcriptome |
Issue Date: | 2011 | Publisher: | EMBO Press | Citation: | Zhang, J, Vaga, S, Chumnanpuen, P, Kumar, R, Vemuri, G.N, Aebersold, R, Nielsen, J (2011). Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae. Molecular Systems Biology 7 : 545. ScholarBank@NUS Repository. https://doi.org/10.1038/msb.2011.80 | Rights: | Attribution 4.0 International | Abstract: | Nutrient sensing and coordination of metabolic pathways are crucial functions for all living cells, but details of the coordination under different environmental conditions remain elusive. We therefore undertook a systems biology approach to investigate the interactions between the Snf1 and the target of rapamycin complex 1 (TORC1) in Saccharomyces cerevisiae. We show that Snf1 regulates a much broader range of biological processes compared with TORC1 under both glucose-and ammonium-limited conditions. We also find that Snf1 has a role in upregulating the NADP +-dependent glutamate dehydrogenase (encoded by GDH3) under derepressing condition, and therefore may also have a role in ammonium assimilation and amino-acid biosynthesis, which can be considered as a convergence of Snf1 and TORC1 pathways. In addition to the accepted role of Snf1 in regulating fatty acid (FA) metabolism, we show that TORC1 also regulates FA metabolism, likely through modulating the peroxisome and Î 2-oxidation. Finally, we conclude that direct interactions between Snf1 and TORC1 pathways are unlikely under nutrient-limited conditions and propose that TORC1 is repressed in a manner that is independent of Snf1. © 2011 EMBO and Macmillan Publishers Limited All rights reserved. | Source Title: | Molecular Systems Biology | URI: | https://scholarbank.nus.edu.sg/handle/10635/178167 | ISSN: | 1744-4292 | DOI: | 10.1038/msb.2011.80 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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