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https://doi.org/10.1186/1749-8546-7-6
DC Field | Value | |
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dc.title | Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B | |
dc.contributor.author | Lu, Y | |
dc.contributor.author | Zheng, Y | |
dc.contributor.author | Liu, X | |
dc.contributor.author | Liang, X | |
dc.contributor.author | Ngai, S | |
dc.contributor.author | Li, T | |
dc.contributor.author | Zhang, W | |
dc.date.accessioned | 2020-10-20T08:07:41Z | |
dc.date.available | 2020-10-20T08:07:41Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Lu, Y, Zheng, Y, Liu, X, Liang, X, Ngai, S, Li, T, Zhang, W (2012). Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B. Chinese Medicine 7 : 6. ScholarBank@NUS Repository. https://doi.org/10.1186/1749-8546-7-6 | |
dc.identifier.issn | 1749-8546 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/178152 | |
dc.description.abstract | Background: Radix Salvia miltiorrhiza (Danshen) has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B), a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI) effect. This study aims to investigate mechanisms of SA-B on MI.Methods: Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine) with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line.Results: The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP) and Ca2+and inhibiting protein kinase A (PKA).Conclusion: SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism. © 2012 Lu et al; licensee BioMed Central Ltd. | |
dc.publisher | BMC | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | calcium ion | |
dc.subject | captopril | |
dc.subject | cyclic AMP | |
dc.subject | cyclic AMP dependent protein kinase | |
dc.subject | isosorbide dinitrate | |
dc.subject | propranolol | |
dc.subject | salvianolic acid B | |
dc.subject | verapamil | |
dc.subject | animal cell | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | article | |
dc.subject | cardiovascular disease | |
dc.subject | cell line | |
dc.subject | controlled study | |
dc.subject | heart muscle ischemia | |
dc.subject | male | |
dc.subject | metabolomics | |
dc.subject | nonhuman | |
dc.subject | rat | |
dc.subject | Salvia miltiorrhiza | |
dc.type | Article | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1186/1749-8546-7-6 | |
dc.description.sourcetitle | Chinese Medicine | |
dc.description.volume | 7 | |
dc.description.page | 6 | |
dc.published.state | published | |
Appears in Collections: | Staff Publications Elements |
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