Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2156-8-84
Title: A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
Authors: Qiao, Q
Österholm, A.-M
He, B
Pitkäniemi, J
Cordell, H.J
Sarti, C
Kinnunen, L
Tuomilehto-Wolf, E
Tryggvason, K 
Tuomilehto, J
Keywords: HLA antigen
HLA DR3 antigen
HLA DR4 antigen
insulin
adolescent
adult
article
familial incidence
Finland
gene frequency
gene mapping
genetic association
genetic heterogeneity
genetic linkage
genetic predisposition
genetic risk
genetic screening
genetic susceptibility
genotype
histocompatibility gene
human
immunogenetics
insulin dependent diabetes mellitus
linkage analysis
major clinical study
mass screening
microsatellite marker
nonhuman
nuclear family
school child
sibling
single nucleotide polymorphism
Adolescent
Adult
Child
Child, Preschool
Chromosome Mapping
Chromosomes, Human
Diabetes Mellitus, Type 1
Finland
Genetic Linkage
Genetic Predisposition to Disease
Humans
Infant
Middle Aged
Nuclear Family
Siblings
Issue Date: 2007
Citation: Qiao, Q, Österholm, A.-M, He, B, Pitkäniemi, J, Cordell, H.J, Sarti, C, Kinnunen, L, Tuomilehto-Wolf, E, Tryggvason, K, Tuomilehto, J (2007). A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland. BMC Genetics 8 : 84. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2156-8-84
Rights: Attribution 4.0 International
Abstract: Background: A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles. Results: In addition to the evidence of linkage to the HLA region on 6p21 (nominal p = 4.0 × 10-6), significant evidence of linkage in other chromosome regions was not detected with a single-locus analysis. The two-locus analysis conditional on the HLA gave a maximum lod score (MLS) of 3.1 (nominal p = 2 × 10-4) on chromosome 9p13 under an additive model; MLS of 2.1 (nominal p = 6.1 × 10-3) on chromosome 17p12 and MLS of 2.5 (nominal p = 2.9 × 10-3) on chromosome 18p11 under a general model. Conclusion: Our genome scan data confirmed the primary contribution of the HLA genes also in the high-risk Finnish population, and suggest that non-HLA genes also contribute to the familial clustering of type 1 diabetes in Finland. © 2007 Qiao et al; licensee BioMed Central Ltd.
Source Title: BMC Genetics
URI: https://scholarbank.nus.edu.sg/handle/10635/177983
ISSN: 14712156
DOI: 10.1186/1471-2156-8-84
Rights: Attribution 4.0 International
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