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Title: | MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage | Authors: | Tan, Y.M Østergaard, M Doyle, A Dalbeth, N Lobo, M Reeves, Q Robinson, E Taylor, W.J Jones, P.B Pui, K Lee, J McQueen, F.M |
Keywords: | azathioprine C reactive protein cyclosporin hydroxychloroquine leflunomide methotrexate nonsteroid antiinflammatory agent prednisone salazosulfapyridine adult article bone erosion bone injury bone radiography bone swelling clinical article contrast enhancement controlled study correlation coefficient disease activity disease duration disease severity female foot radiography hand radiography human image analysis joint radiography male pain assessment psoriatic arthritis reliability scoring system arthrography bone edema joint middle aged nuclear magnetic resonance imaging pathology psoriatic arthritis radiography Adult Arthritis, Psoriatic Arthrography Bone and Bones Edema Humans Joints Magnetic Resonance Imaging Middle Aged |
Issue Date: | 2009 | Citation: | Tan, Y.M, Østergaard, M, Doyle, A, Dalbeth, N, Lobo, M, Reeves, Q, Robinson, E, Taylor, W.J, Jones, P.B, Pui, K, Lee, J, McQueen, F.M (2009). MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage. Arthritis Research and Therapy 11 (1) : R2. ScholarBank@NUS Repository. https://doi.org/10.1186/ar2586 | Rights: | Attribution 4.0 International | Abstract: | Introduction: The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA). Methods: Twenty-eight patients with erosive PsA were enrolled (median disease duration of 14 years). Using x-rays of both hands and feet, 11 patients were classified as AM and 17 as non-AM (erosive psoriatic arthritis without bone lysis)by two observers. MRI scans (1.5T) of the dominant hand (wrist and fingers scanned separately) were obtained using standard contrast-enhanced T1-weighted and fat-saturated T2-weighted sequences. Scans were scored separately by two readers for bone erosion, oedema and proliferation using a PsA MRI scoring system. X-rays were scored for erosions and joint space narrowing. Results: On MRI, 1013 bones were scored by both readers. Reliability for scoring erosions and bone oedema was high (intraclass correlation coefficients = 0.80 and 0.77 respectively) but only fair for bone proliferation (intraclass correlation coefficient = 0.42). MRI erosion scores were higher in AM patients (53.0 versus 15.0, p = 0.004) as were bone oedema and proliferation scores (14.7 versus 10.0, p = 0.056 and 3.6 versus 0.7, p = 0.003 respectively). MRI bone oedema scores correlated with MRI erosion scores and X-ray erosion and joint space narrowing scores (r = 0.65, p = 0.0002 for all) but not the disease activity score 28-C reactive protein (DAS28CRP) or pain scores. Conclusions: In this patient group with PsA, MRI bone oedema, erosion and proliferation were all more severe in the AM-form. Bone oedema scores did not correlate with disease activity measures but were closely associated with X-ray joint damage scores. These results suggest that MRI bone oedema may be a pre-erosive feature and that bone damage may not be coupled with joint inflammation in PsA. © 2009 Tan et al.; licensee BioMed Central Ltd. | Source Title: | Arthritis Research and Therapy | URI: | https://scholarbank.nus.edu.sg/handle/10635/177961 | ISSN: | 14786354 | DOI: | 10.1186/ar2586 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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