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|Title:||Latent tuberculosis in patients with diabetes mellitus: prevalence, progression and public health implications||Authors:||Leow M.K.
|Issue Date:||2014||Citation:||Leow M.K., Dalan R., Chee C.B., Earnest A., Chew D.E., Tan A.W., Kon W.Y., Jong M., Barkham T., Wang Y.T. (2014). Latent tuberculosis in patients with diabetes mellitus: prevalence, progression and public health implications. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 122 (9) : 528 - 532. ScholarBank@NUS Repository. https://doi.org/10.1055/s-0034-1377044||Abstract:||BACKGROUND: Diabetes mellitus (DM) confers a higher risk for tuberculosis (TB). Yet, TB screening and chemoprophylaxis for latent TB infection (LTBI) in DM remains controversial. We conducted a cross-sectional study to elucidate LTBI prevalence and longitudinal follow-up to ascertain LTBI to active TB progression rate in DM.METHODS: 220 DM patients without previous TB from the outpatient diabetes clinic of the hospital were enrolled. T-Spot TB, tuberculin-skin-test (TST) and chest radiography (CXR) were performed. LTBI was defined by negative CXR with reactive T-Spot TB. Progression to active TB was confirmed by cross-checking against the TB registry.RESULTS: The prevalence of LTBI was 28.2% (62/220) by reactive T-Spot. None progressed to active TB from 2007-2013. Multivariate analysis revealed that any co-morbidity (p=0.016) was positively associated while metformin (p=0.008) was negatively associated with LTBI.CONCLUSIONS: Over a quarter of DM patients harbor LTBI. While the lack of demonstrable progression to active TB within the follow-up time frame up to this point does not unequivocally support a routine TB screening policy or anti-TB chemoprophylaxis for LTBI in a diabetic population for now, this preliminary evidence needs re-evaluation with longer follow-up of this enrolled cohort over the next decade. J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York.||Source Title:||Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association||URI:||https://scholarbank.nus.edu.sg/handle/10635/177741||ISSN:||14393646||DOI:||10.1055/s-0034-1377044|
|Appears in Collections:||Staff Publications|
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