Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphys.2020.00949
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dc.titleRole of Histone Deacetylases in Skeletal Muscle Physiology and Systemic Energy Homeostasis: Implications for Metabolic Diseases and Therapy
dc.contributor.authorTian H.
dc.contributor.authorLiu S.
dc.contributor.authorRen J.
dc.contributor.authorLee J.K.W.
dc.contributor.authorWang R.
dc.contributor.authorChen P.
dc.date.accessioned2020-10-16T07:27:27Z
dc.date.available2020-10-16T07:27:27Z
dc.date.issued2020
dc.identifier.citationTian H., Liu S., Ren J., Lee J.K.W., Wang R., Chen P. (2020). Role of Histone Deacetylases in Skeletal Muscle Physiology and Systemic Energy Homeostasis: Implications for Metabolic Diseases and Therapy. Frontiers in Physiology 11. ScholarBank@NUS Repository. https://doi.org/10.3389/fphys.2020.00949
dc.identifier.issn1664042X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/177646
dc.description.abstractSkeletal muscle is the largest metabolic organ in the human body and is able to rapidly adapt to drastic changes during exercise. Histone acetyltransferases (HATs) and histone deacetylases (HDACs), which target histone and non-histone proteins, are two major enzyme families that control the biological process of histone acetylation and deacetylation. Balance between these two enzymes serves as an essential element for gene expression and metabolic and physiological function. Genetic KO/TG murine models reveal that HDACs possess pivotal roles in maintaining skeletal muscles? metabolic homeostasis, regulating skeletal muscles motor adaptation and exercise capacity. HDACs may be involved in mitochondrial remodeling, insulin sensitivity regulation, turn on/off of metabolic fuel switching and orchestrating physiological homeostasis of skeletal muscles from the process of myogenesis. Moreover, many myogenic factors and metabolic factors are modulated by HDACs. HDACs are considered as therapeutic targets in clinical research for treatment of cancer, inflammation, and neurological and metabolic-related diseases. This review will focus on physiological function of HDACs in skeletal muscles and provide new ideas for the treatment of metabolic diseases. © Copyright © 2020 Tian, Liu, Ren, Lee, Wang and Chen.
dc.publisherFrontiers Media S.A.
dc.sourceScopus
dc.subjectexercise capacity
dc.subjecthistone deacetylases
dc.subjectmetabolism
dc.subjectmuscle physiology
dc.subjectskeletal muscle
dc.typeReview
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.3389/fphys.2020.00949
dc.description.sourcetitleFrontiers in Physiology
dc.description.volume11
dc.published.statePublished
dc.grant.id2019M651553
dc.grant.id019M661042
dc.grant.id81501071
dc.grant.fundingagencyChina Postdoctoral Science Foundation
dc.grant.fundingagencyNational Natural Science Foundation of China,ÿNSFC
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