Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphys.2020.00949
Title: Role of Histone Deacetylases in Skeletal Muscle Physiology and Systemic Energy Homeostasis: Implications for Metabolic Diseases and Therapy
Authors: Tian H.
Liu S.
Ren J.
Lee J.K.W. 
Wang R.
Chen P.
Keywords: exercise capacity
histone deacetylases
metabolism
muscle physiology
skeletal muscle
Issue Date: 2020
Publisher: Frontiers Media S.A.
Citation: Tian H., Liu S., Ren J., Lee J.K.W., Wang R., Chen P. (2020). Role of Histone Deacetylases in Skeletal Muscle Physiology and Systemic Energy Homeostasis: Implications for Metabolic Diseases and Therapy. Frontiers in Physiology 11. ScholarBank@NUS Repository. https://doi.org/10.3389/fphys.2020.00949
Abstract: Skeletal muscle is the largest metabolic organ in the human body and is able to rapidly adapt to drastic changes during exercise. Histone acetyltransferases (HATs) and histone deacetylases (HDACs), which target histone and non-histone proteins, are two major enzyme families that control the biological process of histone acetylation and deacetylation. Balance between these two enzymes serves as an essential element for gene expression and metabolic and physiological function. Genetic KO/TG murine models reveal that HDACs possess pivotal roles in maintaining skeletal muscles? metabolic homeostasis, regulating skeletal muscles motor adaptation and exercise capacity. HDACs may be involved in mitochondrial remodeling, insulin sensitivity regulation, turn on/off of metabolic fuel switching and orchestrating physiological homeostasis of skeletal muscles from the process of myogenesis. Moreover, many myogenic factors and metabolic factors are modulated by HDACs. HDACs are considered as therapeutic targets in clinical research for treatment of cancer, inflammation, and neurological and metabolic-related diseases. This review will focus on physiological function of HDACs in skeletal muscles and provide new ideas for the treatment of metabolic diseases. © Copyright © 2020 Tian, Liu, Ren, Lee, Wang and Chen.
Source Title: Frontiers in Physiology
URI: https://scholarbank.nus.edu.sg/handle/10635/177646
ISSN: 1664042X
DOI: 10.3389/fphys.2020.00949
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
fphys-11-00949.pdf1.06 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

1
checked on Jun 7, 2021

Page view(s)

55
checked on Jun 11, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.