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dc.titleVisceral adipose tissue tracks more closely with metabolic dysfunction than intrahepatic triglyceride in lean Asians without diabetes
dc.contributor.authorDing C.
dc.contributor.authorChan Z.
dc.contributor.authorChooi Y.C.
dc.contributor.authorChoo J.
dc.contributor.authorSadananthan S.A.
dc.contributor.authorMichael N.
dc.contributor.authorSendhil Velan S.
dc.contributor.authorLeow M.K.S.
dc.contributor.authorMagkos F.
dc.identifier.citationDing C., Chan Z., Chooi Y.C., Choo J., Sadananthan S.A., Michael N., Sendhil Velan S., Leow M.K.S., Magkos F. (2018). Visceral adipose tissue tracks more closely with metabolic dysfunction than intrahepatic triglyceride in lean Asians without diabetes. Journal of Applied Physiology 125 (3) : 909 - 915. ScholarBank@NUS Repository.
dc.description.abstractIncreased visceral adipose tissue (VAT) and intrahepatic triglyceride (IHTG) are important risk factors for the development of type 2 diabetes in subjects with obesity. The relative contribution of these ectopic fat depots to cardiometabolic risk differs between populations, depends on the degree of obesity and the level of cardiorespiratory fitness, and is difficult to dissect because VAT and IHTG typically covary. The aim of this study was to evaluate the effect of an isolated increase in VAT or IHTG on insulin sensitivity and insulin secretion in apparently healthy normal-weight Asian subjects. Total body fat (dual X-ray absorptiometry), VAT and IHTG (magnetic resonance), insulin sensitivity (4-h hyperinsulinemic-euglycemic clamp), beta cell responsivity and insulin secretion rate (3-h mixed meal with mathematical modeling), and cardiorespiratory fitness (maximal oxygen consumption [V O 2max ]) were evaluated in groups of lean subjects with low or high VAT (687 94 vs. 1,279 197 ml, matched for IHTG; n 13 each) and low or high IHTG (1.7 0.3 vs. 6.7 2.0%, matched for VAT; n 15 each). All groups were matched for age, sex, total body fat, and V O2max. High-VAT subjects had ~25% lower insulin sensitivity, ~20%-40% greater beta cell responsivity and insulin secretion rate, ~35% greater fasting triglyceride concentration, and ~40% lower adiponectin concentration than low-VAT subjects (all P 0.05). No differences were observed between low-IHTG and high-IHTG subjects. Accumulation of excess fat in the intra-abdominal area is more strongly associated with metabolic dysfunction than accumulation of liver fat in lean Asians without diabetes. NEW & NOTEWORTHY It is not known whether metabolic abnormalities in Asians without obesity track more closely with visceral or liver fat. We found an isolated increase in visceral fat was associated with reduced insulin sensitivity, greater insulin secretion, greater triglyceride, and lower adiponectin concentrations; no differences were observed with an isolated increase in liver fat. These results suggest that visceral fat is a better correlate of metabolic dysfunction than liver fat in Asians without obesity. 2018 the American Physiological Society
dc.publisherAmerican Physiological Society
dc.subjectcell function
dc.subjectInsulin secretion
dc.subjectInsulin sensitivity
dc.subjectLiver fat
dc.subjectVisceral fat
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.sourcetitleJournal of Applied Physiology
dc.description.page909 - 915
dc.grant.fundingagencySingapore Institute for Clinical Sciences, SICS
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