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Title: Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians
Authors: Chan Z.
Ding C.
Chooi Y.C.
Choo J.
Sadananthan S.A.
Sasikala S.
Chang A.
Michael N.
Velan S.S.
Leow M.K.S. 
Magkos F. 
Keywords: diabetes
metabolic function
physical activity
Issue Date: 2019
Publisher: Blackwell Publishing Ltd
Citation: Chan Z., Ding C., Chooi Y.C., Choo J., Sadananthan S.A., Sasikala S., Chang A., Michael N., Velan S.S., Leow M.K.S., Magkos F. (2019). Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians. European Journal of Clinical Investigation 49 (5). ScholarBank@NUS Repository.
Abstract: Background The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in subjects from the nonobese Asians is not known. Materials and methods We conducted a cross‐sectional study and measured insulin sensitivity (M value; 4‐hour hyperinsulinaemic‐euglycaemic clamp), insulin secretion rate (3‐hour mixed meal tolerance test with oral minimal modelling), percent body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy nonobese Asian subjects (BMI = 21.9 ± 1.7 kg/m2, age = 41.8 ± 13.4 years). Results M was inversely associated with percent body fat (r = −0.460, P < 0.001), visceral fat (r = −0.623, P < 0.001) and liver fat (r = −0.601, P < 0.001), whereas insulin secretion correlated positively with these adiposity indices (percent body fat: r = 0.303, P = 0.018; visceral fat: r = 0.409, P = 0.010; hepatic fat: r = 0.393, P = 0.002). VO2max correlated negatively with insulin secretion rate (r = −0.420, P < 0.001) and positively with M (r = 0.658, P < 0.001). The amount of vigorous physical activity was positively associated with VO2max (r = 0.682, P < 0.001). Multiple stepwise linear regression analyses indicated that VO2max, age, and IHTG or VAT were independent determinants of insulin sensitivity and secretion (adjusted R2 = 69% and 33%, respectively, P < 0.001). Conclusions Increased ectopic fat deposition is associated with reduced insulin sensitivity and increased insulin secretion in healthy nonobese Asians. Poor cardiorespiratory fitness, likely due to inadequate participation in vigorous exercise, is strongly related to suboptimal metabolic function. Interventions to encourage engagement in physical activity may thus be important for improving metabolic health in nonobese Asians.
Source Title: European Journal of Clinical Investigation
ISSN: 0014-2972
DOI: 10.1111/eci.13079
Appears in Collections:Staff Publications

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