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https://doi.org/10.1111/jocs.14880
Title: | FFR-guided versus coronary angiogram-guided CABG: A review and meta-analysis of prospective randomized controlled trials | Authors: | Timbadia, Dhayan Ler, Ashlynn Sazzad, Faizus Alexiou, Christos Kofidis, Theo |
Keywords: | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Surgery Cardiovascular System & Cardiology coronary angiography coronary artery bypass coronary artery disease fractional flow reserve meta-analysis FRACTIONAL FLOW RESERVE BYPASS GRAFT-SURGERY 5-YEAR FOLLOW-UP INTERVENTION SEVERITY STENOSIS PATENCY |
Issue Date: | 22-Jul-2020 | Publisher: | WILEY | Citation: | Timbadia, Dhayan, Ler, Ashlynn, Sazzad, Faizus, Alexiou, Christos, Kofidis, Theo (2020-07-22). FFR-guided versus coronary angiogram-guided CABG: A review and meta-analysis of prospective randomized controlled trials. JOURNAL OF CARDIAC SURGERY 35 (10). ScholarBank@NUS Repository. https://doi.org/10.1111/jocs.14880 | Abstract: | © 2020 Wiley Periodicals LLC Background: Fractional flow reserve (FFR) is a well-established method for the evaluation of coronary artery stenosis before percutaneous coronary intervention. However, whether FFR assessment should be routinely used before coronary artery bypass graft surgery (CABG) remains unclear. A meta-analysis of prospectively randomized controlled trials (PRCTs) was carried out to compare the outcomes of FFR-guided CABG vs coronary angiography (CAG)-guided CABG. Method: The meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Two PRCTs (the FARGO and GRAFFITI trials) were found and included reporting data on 269 patients with 6 and 12 month follow-up. Primary endpoints were rates of overall death, MACCE, target vessel revascularization, and spontaneous myocardial infarction (MI). Secondary endpoints were overall graft patency and patency of arterial and venous grafts. Results: There were no significant differences between the FFR-guided and CAG-guided groups in the rates of overall death, MACCE, target vessel revascularization, spontaneous MI and graft patency. Meta-analysis of FARGO and GRAFFITI PRCTs showed that FFR-guided CABG and CAG-guided CABG produced similar clinical outcomes with similar graft patency rates up to a year postoperatively. Conclusion: Currently available PRCTs showes no sufficient evidence to support the use FFR in CABG. | Source Title: | JOURNAL OF CARDIAC SURGERY | URI: | https://scholarbank.nus.edu.sg/handle/10635/177370 | ISSN: | 08860440 15408191 |
DOI: | 10.1111/jocs.14880 |
Appears in Collections: | Staff Publications Elements |
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