Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijerph15050889
Title: Association of insulin resistance with bone strength and bone turnover in menopausal Chinese-singaporean women without diabetes
Authors: Kalimeri, M 
Leek, F 
Wang, N.X
Koh, H.R
Roy, N.C
Cameron-Smith, D
Kruger, M.C
Henry, C.J 
Totman, J.J 
Keywords: carboxy terminal telopeptide
colecalciferol
collagen type 1
glucose
insulin
parathyroid hormone
collagen type 1
collagen type I trimeric cross-linked peptide
parathyroid hormone
peptide
blood
bone
carbohydrate
developing world
diabetes
hormone
vitamin
womens health
adult
aged
Article
body composition
bone density
bone metabolism
bone strength
bone turnover
Chinese
cohort analysis
controlled study
dysglycemia
fat mass
female
femoral neck
glucose metabolism
human
insulin dependent diabetes mellitus
insulin resistance
lean body weight
liquid chromatography
liver metabolism
lumbar spine
lumbar vertebra
major clinical study
menopause
non insulin dependent diabetes mellitus
proximal femur
Singaporean
tandem mass spectrometry
volumetry
x-ray computed tomography
blood
bone remodeling
femur
insulin resistance
metabolism
middle aged
physiology
Aged
Bone Density
Bone Remodeling
Cholecalciferol
Collagen Type I
Female
Femur
Humans
Insulin Resistance
Lumbar Vertebrae
Menopause
Middle Aged
Parathyroid Hormone
Peptides
Issue Date: 2018
Citation: Kalimeri, M, Leek, F, Wang, N.X, Koh, H.R, Roy, N.C, Cameron-Smith, D, Kruger, M.C, Henry, C.J, Totman, J.J (2018). Association of insulin resistance with bone strength and bone turnover in menopausal Chinese-singaporean women without diabetes. International Journal of Environmental Research and Public Health 15 (5) : 889. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph15050889
Abstract: Insulin resistance (IR) is accompanied by increased areal or volumetric bone mineral density (aBMD or vBMD), but also higher fracture risk. Meanwhile, imbalances in bone health biomarkers affect insulin production. This study investigates the effect of IR on proximal femur and lumbar spine BMD, femoral neck bending, compressive and impact strength indices (Composite Strength Indices) and circulating levels of parathyroid hormone (PTH), C-telopeptide of Type I collagen (CTx-1) and 25(OH) Vitamin D3, in a cohort of 97 healthy, non-obese, menopausal Chinese-Singaporean women. Lumbar spine aBMD was inversely associated with IR and dependent on lean body mass (LBM) and age. No such associations were found for vBMD of the third lumbar vertebra, aBMD and vBMD of the proximal femur, or circulating levels of PTH, CTx-1 and 25(OH) Vitamin D3. Composite Strength Indices were inversely associated with IR and independent of LBM, but after adjusting for fat mass and age, this association remained valid only for the impact strength index. Composite Strength Indices were significantly lower in participants with a high degree of IR. Our findings on IR and Composite Strength Indices relationships were in agreement with previous studies on different cohorts, but those on IR and BMD associations were not. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Environmental Research and Public Health
URI: https://scholarbank.nus.edu.sg/handle/10635/176204
ISSN: 1661-7827
DOI: 10.3390/ijerph15050889
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