Please use this identifier to cite or link to this item:
https://doi.org/10.3390/ijerph15102073
DC Field | Value | |
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dc.title | Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder | |
dc.contributor.author | Ho, R.C.M | |
dc.contributor.author | Chua, A.C | |
dc.contributor.author | Tran, B.X | |
dc.contributor.author | Choo, C.C | |
dc.contributor.author | Husain, S.F | |
dc.contributor.author | Vu, G.T | |
dc.contributor.author | McIntyre, R.S | |
dc.contributor.author | Ho, C.S.H | |
dc.date.accessioned | 2020-09-14T08:27:50Z | |
dc.date.available | 2020-09-14T08:27:50Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Ho, R.C.M, Chua, A.C, Tran, B.X, Choo, C.C, Husain, S.F, Vu, G.T, McIntyre, R.S, Ho, C.S.H (2018). Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder. International Journal of Environmental Research and Public Health 15 (10) : 2073. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph15102073 | |
dc.identifier.issn | 1661-7827 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/176198 | |
dc.description.abstract | Background: The aim of this study was to identify factors associated with high Framingham Risk Score (FRS) in medicated patients with major depressive disorder (MDD). Methods: We examined 61 medicated patients with MDD (mean age 37.77 ± 7.67, 90.2% women) and 43 non-depressed controls (mean age 38.26 ± 9.20, 90.7% women). We administered the Hamilton Depression Rating Scale (HAM-D) and measured systolic blood pressure (SBP), diastolic BP (DBP), mean arterial BP (MAP), pulse wave velocity (PWV), intima-media thickness (IMT), interleukin-6 (IL-6) and triglycerides. Results: We found that medicated patients with MDD had significantly higher levels of HAM-D score (p < 0.01), SBP (p = 0.015), MAP (p = 0.037), IL−6 level (p = 0.007), as compared with controls. Medicated patients who remained moderately to severely depressed showed significantly higher SBP (p = 0.049), DBP (p = 0.009), MAP (p = 0.024), IL−6 level (p = 0.019), left PWV (p = 0.004) and average PWV (p = 0.026) than those with mild depression. Multivariate regression showed that the interaction effect between HAM-D score and triglyceride level (p = 0.018) was significantly associated with FRS in medicated patients with MDD. Conclusions: This study highlights that the interaction effect of the severity of depression and the triglyceride level, was a modifiable factor positively associated with high FRS. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.source | Unpaywall 20200831 | |
dc.subject | antidepressant agent | |
dc.subject | interleukin 6 | |
dc.subject | triacylglycerol | |
dc.subject | cardiovascular disease | |
dc.subject | fat | |
dc.subject | health risk | |
dc.subject | mental health | |
dc.subject | protein | |
dc.subject | public health | |
dc.subject | regression analysis | |
dc.subject | womens health | |
dc.subject | adult | |
dc.subject | arterial wall thickness | |
dc.subject | Article | |
dc.subject | cardiovascular risk | |
dc.subject | coronary artery disease | |
dc.subject | diastolic blood pressure | |
dc.subject | disease severity | |
dc.subject | female | |
dc.subject | Framingham risk score | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | major depression | |
dc.subject | male | |
dc.subject | mean arterial pressure | |
dc.subject | pulse wave | |
dc.subject | risk assessment | |
dc.subject | systolic blood pressure | |
dc.subject | case control study | |
dc.subject | complication | |
dc.subject | coronary artery disease | |
dc.subject | cross-sectional study | |
dc.subject | major depression | |
dc.subject | middle aged | |
dc.subject | pathophysiology | |
dc.subject | psychological rating scale | |
dc.subject | risk factor | |
dc.subject | severity of illness index | |
dc.subject | Adult | |
dc.subject | Antidepressive Agents | |
dc.subject | Case-Control Studies | |
dc.subject | Coronary Artery Disease | |
dc.subject | Cross-Sectional Studies | |
dc.subject | Depressive Disorder, Major | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Psychiatric Status Rating Scales | |
dc.subject | Risk Factors | |
dc.subject | Severity of Illness Index | |
dc.type | Article | |
dc.contributor.department | PSYCHOLOGICAL MEDICINE | |
dc.description.doi | 10.3390/ijerph15102073 | |
dc.description.sourcetitle | International Journal of Environmental Research and Public Health | |
dc.description.volume | 15 | |
dc.description.issue | 10 | |
dc.description.page | 2073 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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