Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijerph15102073
Title: Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder
Authors: Ho, R.C.M 
Chua, A.C
Tran, B.X
Choo, C.C
Husain, S.F 
Vu, G.T
McIntyre, R.S
Ho, C.S.H
Keywords: antidepressant agent
interleukin 6
triacylglycerol
cardiovascular disease
fat
health risk
mental health
protein
public health
regression analysis
womens health
adult
arterial wall thickness
Article
cardiovascular risk
coronary artery disease
diastolic blood pressure
disease severity
female
Framingham risk score
human
major clinical study
major depression
male
mean arterial pressure
pulse wave
risk assessment
systolic blood pressure
case control study
complication
coronary artery disease
cross-sectional study
major depression
middle aged
pathophysiology
psychological rating scale
risk factor
severity of illness index
Adult
Antidepressive Agents
Case-Control Studies
Coronary Artery Disease
Cross-Sectional Studies
Depressive Disorder, Major
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Risk Factors
Severity of Illness Index
Issue Date: 2018
Citation: Ho, R.C.M, Chua, A.C, Tran, B.X, Choo, C.C, Husain, S.F, Vu, G.T, McIntyre, R.S, Ho, C.S.H (2018). Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder. International Journal of Environmental Research and Public Health 15 (10) : 2073. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph15102073
Abstract: Background: The aim of this study was to identify factors associated with high Framingham Risk Score (FRS) in medicated patients with major depressive disorder (MDD). Methods: We examined 61 medicated patients with MDD (mean age 37.77 ± 7.67, 90.2% women) and 43 non-depressed controls (mean age 38.26 ± 9.20, 90.7% women). We administered the Hamilton Depression Rating Scale (HAM-D) and measured systolic blood pressure (SBP), diastolic BP (DBP), mean arterial BP (MAP), pulse wave velocity (PWV), intima-media thickness (IMT), interleukin-6 (IL-6) and triglycerides. Results: We found that medicated patients with MDD had significantly higher levels of HAM-D score (p < 0.01), SBP (p = 0.015), MAP (p = 0.037), IL−6 level (p = 0.007), as compared with controls. Medicated patients who remained moderately to severely depressed showed significantly higher SBP (p = 0.049), DBP (p = 0.009), MAP (p = 0.024), IL−6 level (p = 0.019), left PWV (p = 0.004) and average PWV (p = 0.026) than those with mild depression. Multivariate regression showed that the interaction effect between HAM-D score and triglyceride level (p = 0.018) was significantly associated with FRS in medicated patients with MDD. Conclusions: This study highlights that the interaction effect of the severity of depression and the triglyceride level, was a modifiable factor positively associated with high FRS. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Environmental Research and Public Health
URI: https://scholarbank.nus.edu.sg/handle/10635/176198
ISSN: 1661-7827
DOI: 10.3390/ijerph15102073
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