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https://doi.org/10.3390/ijms17050598
Title: | Identification of 42 genes linked to stage II colorectal cancer metastatic relapse | Authors: | Al-Temaimi, R.A Tan, T.Z Marafie, M.J Thiery, J.P Quirke, P Al-Mulla, F |
Keywords: | Article cancer mortality cancer recurrence colorectal cancer comparative genomic hybridization copy number variation disease free survival distant metastasis epithelial mesenchymal transition gene expression gene identification growth regulation human human tissue metastasis microarray analysis microsatellite instability overall survival protein expression signal transduction survival analysis aged algorithm cancer staging chromosome aberration cluster analysis colorectal tumor female genetic database genetics male metastasis middle aged mortality pathology proportional hazards model survival rate tumor recurrence microsatellite DNA Aged Algorithms Chromosome Aberrations Cluster Analysis Colorectal Neoplasms Comparative Genomic Hybridization Databases, Genetic Epithelial-Mesenchymal Transition Female Humans Male Microsatellite Repeats Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasm Staging Proportional Hazards Models Survival Rate |
Issue Date: | 2016 | Citation: | Al-Temaimi, R.A, Tan, T.Z, Marafie, M.J, Thiery, J.P, Quirke, P, Al-Mulla, F (2016). Identification of 42 genes linked to stage II colorectal cancer metastatic relapse. International Journal of Molecular Sciences 17 (5) : 598. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms17050598 | Abstract: | Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Metastasis remains the primary cause of CRC death. Predicting the possibility of metastatic relapse in early-stage CRC is of paramount importance to target therapy for patients who really need it and spare those with low-potential of metastasis. Ninety-six stage II CRC cases were stratified using high-resolution array comparative genomic hybridization (aCGH) data based on a predictive survival algorithm and supervised clustering. All genes included within the resultant copy number aberrations were each interrogated independently at mRNA level using CRC expression datasets available from public repositories, which included 1820 colon cancers, and 167 normal colon tissues. Reduced mRNA expression driven by copy number losses and increased expression driven by copy number gains revealed 42 altered transcripts (29 reduced and 13 increased transcripts) associated with metastatic relapse, short disease-free or overall survival, and/or epithelial to mesenchymal transition (EMT). Resultant genes were classified based on gene ontology (GO), which identified four functional enrichment groups involved in growth regulation, genomic integrity, metabolism, and signal transduction pathways. The identified 42 genes may be useful for predicting metastatic relapse in stage II CRC. Further studies are necessary to validate these findings. © 2016 by the authors; licensee MDPI, Basel, Switzerland. | Source Title: | International Journal of Molecular Sciences | URI: | https://scholarbank.nus.edu.sg/handle/10635/176130 | ISSN: | 1661-6596 | DOI: | 10.3390/ijms17050598 |
Appears in Collections: | Elements Staff Publications |
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