Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms17050598
Title: Identification of 42 genes linked to stage II colorectal cancer metastatic relapse
Authors: Al-Temaimi, R.A
Tan, T.Z 
Marafie, M.J
Thiery, J.P 
Quirke, P
Al-Mulla, F
Keywords: Article
cancer mortality
cancer recurrence
colorectal cancer
comparative genomic hybridization
copy number variation
disease free survival
distant metastasis
epithelial mesenchymal transition
gene expression
gene identification
growth regulation
human
human tissue
metastasis
microarray analysis
microsatellite instability
overall survival
protein expression
signal transduction
survival analysis
aged
algorithm
cancer staging
chromosome aberration
cluster analysis
colorectal tumor
female
genetic database
genetics
male
metastasis
middle aged
mortality
pathology
proportional hazards model
survival rate
tumor recurrence
microsatellite DNA
Aged
Algorithms
Chromosome Aberrations
Cluster Analysis
Colorectal Neoplasms
Comparative Genomic Hybridization
Databases, Genetic
Epithelial-Mesenchymal Transition
Female
Humans
Male
Microsatellite Repeats
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Proportional Hazards Models
Survival Rate
Issue Date: 2016
Citation: Al-Temaimi, R.A, Tan, T.Z, Marafie, M.J, Thiery, J.P, Quirke, P, Al-Mulla, F (2016). Identification of 42 genes linked to stage II colorectal cancer metastatic relapse. International Journal of Molecular Sciences 17 (5) : 598. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms17050598
Abstract: Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Metastasis remains the primary cause of CRC death. Predicting the possibility of metastatic relapse in early-stage CRC is of paramount importance to target therapy for patients who really need it and spare those with low-potential of metastasis. Ninety-six stage II CRC cases were stratified using high-resolution array comparative genomic hybridization (aCGH) data based on a predictive survival algorithm and supervised clustering. All genes included within the resultant copy number aberrations were each interrogated independently at mRNA level using CRC expression datasets available from public repositories, which included 1820 colon cancers, and 167 normal colon tissues. Reduced mRNA expression driven by copy number losses and increased expression driven by copy number gains revealed 42 altered transcripts (29 reduced and 13 increased transcripts) associated with metastatic relapse, short disease-free or overall survival, and/or epithelial to mesenchymal transition (EMT). Resultant genes were classified based on gene ontology (GO), which identified four functional enrichment groups involved in growth regulation, genomic integrity, metabolism, and signal transduction pathways. The identified 42 genes may be useful for predicting metastatic relapse in stage II CRC. Further studies are necessary to validate these findings. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/176130
ISSN: 1661-6596
DOI: 10.3390/ijms17050598
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