Please use this identifier to cite or link to this item: https://doi.org/10.3389/fonc.2016.00274
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dc.titleLimb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: A pilot study
dc.contributor.authorSundar, R
dc.contributor.authorBandla, A
dc.contributor.authorTan, S.S.H
dc.contributor.authorLiao, L.-D
dc.contributor.authorKumarakulasinghe, N.B
dc.contributor.authorJeyasekharan, A.D
dc.contributor.authorOw, S.G.W
dc.contributor.authorHo, J
dc.contributor.authorTan, D.S.P
dc.contributor.authorLim, J.S.J
dc.contributor.authorVijayan, J
dc.contributor.authorTherimadasamy, A.K
dc.contributor.authorHairom, Z
dc.contributor.authorAng, E
dc.contributor.authorAng, S
dc.contributor.authorThakor, N.V
dc.contributor.authorLee, S.-C
dc.contributor.authorWilder-Smith, E.P.V
dc.date.accessioned2020-09-14T08:07:27Z
dc.date.available2020-09-14T08:07:27Z
dc.date.issued2017
dc.identifier.citationSundar, R, Bandla, A, Tan, S.S.H, Liao, L.-D, Kumarakulasinghe, N.B, Jeyasekharan, A.D, Ow, S.G.W, Ho, J, Tan, D.S.P, Lim, J.S.J, Vijayan, J, Therimadasamy, A.K, Hairom, Z, Ang, E, Ang, S, Thakor, N.V, Lee, S.-C, Wilder-Smith, E.P.V (2017). Limb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: A pilot study. Frontiers in Oncology 6 (JAN) : 274. ScholarBank@NUS Repository. https://doi.org/10.3389/fonc.2016.00274
dc.identifier.issn2234-943X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/176102
dc.description.abstractBackground: Peripheral neuropathy (PN) due to paclitaxel is a common dose-limiting toxicity with no effective prevention or treatment. We hypothesize that continuous-flow limb hypothermia can reduce paclitaxel-induced PN. Patients and methods: An internally controlled pilot trial was conducted to investigate the neuroprotective effect of continuous-flow limb hypothermia in breast cancer patients receiving weekly paclitaxel. Patients underwent limb hypothermia of one limb for a duration of 3 h with every paclitaxel infusion, with the contralateral limb used as control. PN was primarily assessed using nerve conduction studies (NCSs) before the start of chemotherapy, and after 1, 3, and 6 months. Skin temperature and tolerability to hypothermia were monitored using validated scores. Results: Twenty patients underwent a total of 218 cycles of continuous-flow limb hypothermia at a coolant temperature of 22°C. Continuous-flow limb hypothermia achieved mean skin temperature reduction of 1.5 ± 0.7°C and was well tolerated, with no premature termination of cooling due to intolerance. Grade 3 PN occurred in 2 patients (10%), grade 2 in 2 (10%), and grade 1 in 12 (60%). Significant correlation was observed between amount of skin cooling and motor nerve amplitude preservation at 6 months (p < 0.0005). Sensory velocity and amplitude in the cooled limbs were less preserved than in the control limbs, but the difference did not attain statistical significance. One patient with a history of diabetes mellitus had significant preservation of compound muscle action potential in the cooled limb on NCS analysis. Conclusion: This study suggests that continuous limb hypothermia accompanying paclitaxel infusion may reduce paclitaxel-induced PN and have therapeutic potential in select patients and warrants further investigation. The method is safe and well tolerated. © 2017 Sundar, Bandla, Tan, Liao, Kumarakulasinghe, Jeyasekharan, Ow, Ho, Tan, Lim, Vijayan, Therimadasamy, Hairom, Ang, Ang, Thakor, Lee and Wilder-Smith.
dc.sourceUnpaywall 20200831
dc.subjectcyclophosphamide
dc.subjectdexamethasone
dc.subjectdiphenhydramine
dc.subjectdoxorubicin
dc.subjecthemoglobin A1c
dc.subjectpaclitaxel
dc.subjectranitidine
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbreast cancer
dc.subjectcancer chemotherapy
dc.subjectclinical article
dc.subjectcontinuous flow limb hypothermia
dc.subjectcontrolled study
dc.subjectcooling
dc.subjectfemale
dc.subjecthuman
dc.subjectinduced hypothermia
dc.subjectmotor nerve conduction
dc.subjectmuscle action potential
dc.subjectneuroprotection
dc.subjectpatient safety
dc.subjectperipheral neuropathy
dc.subjectpilot study
dc.subjectprophylaxis
dc.subjectprospective study
dc.subjectside effect
dc.subjectskin temperature
dc.subjectvisual analog scale
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEPT OF ELECTRICAL & COMPUTER ENGG
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.3389/fonc.2016.00274
dc.description.sourcetitleFrontiers in Oncology
dc.description.volume6
dc.description.issueJAN
dc.description.page274
dc.published.statePublished
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