Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms18040877
Title: Regulation of ubiquitin enzymes in the TGF-β pathway
Authors: Iyengar, P.V 
Keywords: cyclin dependent kinase 8
cyclin dependent kinase 9
deubiquitinase
proteasome
protein kinase B
Smad2 protein
Smad3 protein
Smad4 protein
stress activated protein kinase
synaptophysin
transforming growth factor beta
transforming growth factor beta receptor 1
transforming growth factor beta receptor 2
tumor necrosis factor receptor associated factor 4
tumor necrosis factor receptor associated factor 6
ubiquitin
ubiquitin protein ligase E3
ubiquitin protein ligase NEDD4
proteasome
protein binding
transforming growth factor beta
tumor necrosis factor receptor associated factor 4
ubiquitin
ubiquitin protein ligase
bone disease
breast cancer
enzyme regulation
gene overexpression
glioblastoma
human
immunofluorescence
metastasis
mutational analysis
neddylation
nonhuman
Review
signal transduction
sumoylation
ubiquitination
animal
disease predisposition
metabolism
signal transduction
Animals
Disease Susceptibility
Humans
Proteasome Endopeptidase Complex
Protein Binding
Signal Transduction
Sumoylation
TNF Receptor-Associated Factor 4
Transforming Growth Factor beta
Ubiquitin
Ubiquitin-Protein Ligases
Ubiquitination
Issue Date: 2017
Citation: Iyengar, P.V (2017). Regulation of ubiquitin enzymes in the TGF-β pathway. International Journal of Molecular Sciences 18 (4) : 877. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18040877
Abstract: The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberrations in these enzymes are frequently observed to dysregulate the pathway causing diseases such as bone disorders, cancer and metastasis. These enzymes and their counterparts are increasingly being tested as druggable targets, and thus a deeper understanding of the enzymes is required. This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-β pathway and how they are regulated. © 2017 by the author. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/176094
ISSN: 1661-6596
DOI: 10.3390/ijms18040877
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