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Title: | Regulation of ubiquitin enzymes in the TGF-β pathway | Authors: | Iyengar, P.V | Keywords: | cyclin dependent kinase 8 cyclin dependent kinase 9 deubiquitinase proteasome protein kinase B Smad2 protein Smad3 protein Smad4 protein stress activated protein kinase synaptophysin transforming growth factor beta transforming growth factor beta receptor 1 transforming growth factor beta receptor 2 tumor necrosis factor receptor associated factor 4 tumor necrosis factor receptor associated factor 6 ubiquitin ubiquitin protein ligase E3 ubiquitin protein ligase NEDD4 proteasome protein binding transforming growth factor beta tumor necrosis factor receptor associated factor 4 ubiquitin ubiquitin protein ligase bone disease breast cancer enzyme regulation gene overexpression glioblastoma human immunofluorescence metastasis mutational analysis neddylation nonhuman Review signal transduction sumoylation ubiquitination animal disease predisposition metabolism signal transduction Animals Disease Susceptibility Humans Proteasome Endopeptidase Complex Protein Binding Signal Transduction Sumoylation TNF Receptor-Associated Factor 4 Transforming Growth Factor beta Ubiquitin Ubiquitin-Protein Ligases Ubiquitination |
Issue Date: | 2017 | Citation: | Iyengar, P.V (2017). Regulation of ubiquitin enzymes in the TGF-β pathway. International Journal of Molecular Sciences 18 (4) : 877. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18040877 | Abstract: | The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberrations in these enzymes are frequently observed to dysregulate the pathway causing diseases such as bone disorders, cancer and metastasis. These enzymes and their counterparts are increasingly being tested as druggable targets, and thus a deeper understanding of the enzymes is required. This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-β pathway and how they are regulated. © 2017 by the author. Licensee MDPI, Basel, Switzerland. | Source Title: | International Journal of Molecular Sciences | URI: | https://scholarbank.nus.edu.sg/handle/10635/176094 | ISSN: | 1661-6596 | DOI: | 10.3390/ijms18040877 |
Appears in Collections: | Elements Staff Publications |
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