Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41398-017-0036-z
Title: Psychiatric polygenic risk associates with cortical morphology and functional organization in aging
Authors: Lee, A 
Shen, M
Qiu, A 
Keywords: neurotrophin
somatomedin receptor
transcriptome
transcriptome
adult
aged
Article
brain region
cell aging
controlled study
echo planar imaging
female
frontal cortex
functional connectivity
functional magnetic resonance imaging
GABAergic transmission
gene interaction
genetic risk
genotype
human
image quality
major clinical study
male
mental disease
Mini Mental State Examination
nerve cell plasticity
nerve degeneration
neuroimaging
parietal lobe
signal transduction
superior temporal gyrus
synaptic transmission
synaptogenesis
aging
anatomy and histology
brain cortex
brain mapping
diagnostic imaging
genetic predisposition
genetics
mental disease
middle aged
multifactorial inheritance
nerve tract
nuclear magnetic resonance imaging
physiology
risk factor
very elderly
young adult
Adult
Aged
Aged, 80 and over
Aging
Brain Mapping
Cerebral Cortex
Female
Genetic Predisposition to Disease
Humans
Magnetic Resonance Imaging
Male
Mental Disorders
Middle Aged
Multifactorial Inheritance
Neural Pathways
Risk Factors
Transcriptome
Young Adult
Issue Date: 2017
Citation: Lee, A, Shen, M, Qiu, A (2017). Psychiatric polygenic risk associates with cortical morphology and functional organization in aging. Translational Psychiatry 7 (12) : 1276. ScholarBank@NUS Repository. https://doi.org/10.1038/s41398-017-0036-z
Abstract: Common brain abnormalities in cortical morphology and functional organization are observed in psychiatric disorders and aging, reflecting shared genetic influences. This preliminary study aimed to examine the contribution of a polygenetic risk for psychiatric disorders (PRScross) to aging brain and to identify molecular mechanisms through the use of multimodal brain images, genotypes, and transcriptome data. We showed age-related cortical thinning in bilateral inferior frontal cortex (IFC) and superior temporal gyrus and alterations in the functional connectivity between bilateral IFC and between right IFC and right inferior parietal lobe as a function of PRScross. Interestingly, the genes in PRScross, that contributed most to aging neurodegeneration, were expressed in the functioanlly connected cortical regions. Especially, genes identified through the genotype-functional connectivity association analysis were commonly expressed in both cortical regions and formed strong gene networks with biological processes related to neural plasticity and synaptogenesis, regulated by glutamatergic and GABAergic transmission, neurotrophin signaling, and metabolism. This study suggested integrating genotype and transcriptome with neuroimage data sheds new light on the mechanisms of aging brain. © 2017 The Author(s).
Source Title: Translational Psychiatry
URI: https://scholarbank.nus.edu.sg/handle/10635/176069
ISSN: 2158-3188
DOI: 10.1038/s41398-017-0036-z
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