Construction of Physics-based brain atlas and its application

Abstract

All the attempts for developing various types of atlas in the past were based on capturing anatomy, function, and vasculature. There was not any significant attempt to build any physics-based 3D human brain model on any atlas. For the first time based on hyperviscoelastic polynomial strain energy density function a complete 3D physics-based atlas (PBA) has been developed that contains fully meshed 43 major anatomical structures and brain connections. This is the original contribution compared to other previous research in the current field. The novelty of the work over the other existing model has been described. The proposed model has shown the ability to simulate the deformation for the whole brain as well as individual sub-cortical structures during neurosurgical procedures. This dissertation also illustrates a framework of useful an automated mesh generator, MAVT.