Please use this identifier to cite or link to this item: https://doi.org/10.14814/phy2.12129
Title: Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation
Authors: Chua, E.C.-P
Yeo, S.-C 
Lee, I.T.-G 
Tan, L.-C 
Lau, P 
Tan, S.S
Mien, I.H
Gooley, J.J 
Keywords: actimetry
adult
Article
behavior
body temperature monitoring
circadian rhythm
electrocardiogram
electroencephalogram
eyelid closure
heart rate
heart rate variability
human
human experiment
male
normal human
physiology
Pittsburgh Sleep Quality Index
polysomnography
psychomotor performance
pupillography
questionnaire
retrospective study
sleep deprivation
somnolence
spectroscopy
visual analog scale
Issue Date: 2014
Citation: Chua, E.C.-P, Yeo, S.-C, Lee, I.T.-G, Tan, L.-C, Lau, P, Tan, S.S, Mien, I.H, Gooley, J.J (2014). Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation. Physiological Reports 2 (9) : e12129. ScholarBank@NUS Repository. https://doi.org/10.14814/phy2.12129
Abstract: Some individuals show severe cognitive impairment when sleep deprived, whereas others are able to maintain a high level of performance. Such differences are stable and trait-like, but it is not clear whether these findings generalize to physiologic responses to sleep loss. Here, we analyzed individual differences in behavioral and physiologic measures in healthy ethnic-Chinese male volunteers (n = 12; aged 22–30 years) who were kept awake for at least 26 h in a controlled laboratory environment on two separate occasions. Every 2 h, sustained attention performance was assessed using a 10-min psychomotor vigilance task (PVT), and sleepiness was estimated objectively by determining percentage eyelid closure over the pupil over time (PERCLOS) and blink rate. Between-subject differences in heart rate and its variability, and electroencephalogram (EEG) spectral power were also analyzed during each PVT. To assess stability of individual differences, intraclass correlation coefficients (ICC) were determined using variance components analysis. Consistent with previous work, individual differences in PVT performance were reproducible across study visits, as were baseline sleep measures prior to sleep deprivation. In addition, stable individual differences were observed during sleep deprivation for PERCLOS, blink rate, heart rate and its variability, and EEG spectral power in the alpha frequency band, even after adjusting for baseline differences in these measures (range, ICC = 0.67–0.91). These findings establish that changes in ocular, ECG, and EEG signals are highly reproducible across a night of sleep deprivation, hence raising the possibility that, similar to behavioral measures, physiologic responses to sleep loss are trait-like. © 2014 The Authors.
Source Title: Physiological Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/176017
ISSN: 2051-817X
DOI: 10.14814/phy2.12129
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