Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-17680-w
Title: European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Authors: Weang-Kee Ho
Min-Min Tan
Nasim Mavaddat
Mei-Chee Tai
Shivaani Mariapun
Jingmei Li 
Peh-Joo Ho 
Joe Dennis
Jonathan P. Tyrer
Manjeet K. Bolla
Kyriaki Michailidou
Qin Wang
Daehee Kang
Ji-Yeob Choi
Suniza Jamaris
Xiao-Ou Shu
Sook-Yee Yoon
Sue K. Park
Sung-Won Kim
Chen-Yang Shen
Jyh-Cherng Yu
Ern Yu Tan
Patrick Mun Yew Chan 
Kenneth Muir
Artitaya Lophatananon
Anna H. Wu
Daniel O. Stram
Keitaro Matsuo
Hidemi Ito
Ching Wan Chan 
Joanne Ngeow 
Wei Sean Yong 
Swee Ho Lim
Geok Hoon Lim 
Ava Kwong
Tsun L. Chan
Su Ming Tan
Jaime Seah
Esther M. John
Allison W. Kurian
Woon-Puay Koh 
Chiea Chuen Khor 
Motoki Iwasaki
Taiki Yamaji
Kiak Mien Veronique Tan 
Kiat Tee Benita Tan 
John J. Spinelli
Kristan J. Aronson
Siti Norhidayu Hasan
Kartini Rahmat
Anushya Vijayananthan
Xueling Sim 
Paul D. P. Pharoah
Wei Zheng
Alison M. Dunning
Jacques Simard
Rob Martinus van Dam 
Cheng-Har Yip
Nur Aishah Mohd Taib
Mikael Hartman 
Douglas F. Easton
Soo-Hwang Teo
Antonis C. Antoniou
Keywords: breast cancer, polygenic risk score, screening programmes in Asia
Issue Date: 31-Jul-2020
Publisher: Nature Research
Citation: Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou (2020-07-31). European polygenic risk score for prediction of breast cancer shows similar performance in Asian women 11 (1) : 3833. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-17680-w
Rights: CC0 1.0 Universal
Related Datasets: 10.1038/s41467-020-17680-w
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.
URI: https://scholarbank.nus.edu.sg/handle/10635/175793
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17680-w
Rights: CC0 1.0 Universal
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