Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep15419
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dc.titleGABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect
dc.contributor.authorAng, S.T
dc.contributor.authorLee, A.T.H
dc.contributor.authorFoo, F.C
dc.contributor.authorNg, L
dc.contributor.authorLow, C.-M
dc.contributor.authorKhanna, S
dc.date.accessioned2020-09-10T01:50:10Z
dc.date.available2020-09-10T01:50:10Z
dc.date.issued2015
dc.identifier.citationAng, S.T, Lee, A.T.H, Foo, F.C, Ng, L, Low, C.-M, Khanna, S (2015). GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect. Scientific Reports 5 : 15419. ScholarBank@NUS Repository. https://doi.org/10.1038/srep15419
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175478
dc.description.abstractThe present study explored the functional details of the influence of medial septal region (MSDB) on spectrum of nociceptive behaviours by manipulating intraseptal GABAergic mechanisms. Results showed that formalin-induced acute nociception was not affected by intraseptal microinjection of bicuculline, a GABAA receptor antagonist, or on selective lesion of septal GABAergic neurons. Indeed, the acute nociceptive responses were dissociated from the regulation of sensorimotor behaviour and generation of theta-rhythm by the GABAergic mechanisms in MSDB. The GABAergic lesion attenuated formalin-induced unconditioned cellular response in the anterior cingulate cortex (ACC) and blocked formalin-induced conditioned place avoidance (F-CPA), and as well as the contextual fear induced on conditioning with brief footshock. The effects of lesion on nociceptiveconditioned cellular responses were, however, variable. Interestingly, the lesion attenuated the conditioned representation of experimental context in dorsal hippocampus field CA1 in the F-CPA task. Collectively, the preceding suggests that the MSDB is a nodal centre wherein the GABAergic neurons mediate nociceptive affect-motivation by regulating cellular mechanisms in ACC that confer an aversive value to the noxious stimulus. Further, in conjunction with a modulatory influence on hippocampal contextual processing, MSDB may integrate affect with context as part of associative learning in the F-CPA task.
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subject4 aminobutyric acid A receptor
dc.subject4 aminobutyric acid receptor
dc.subjectbicuculline
dc.subjectformaldehyde
dc.subjectanimal
dc.subjectanimal behavior
dc.subjectchemically induced
dc.subjectcingulate gyrus
dc.subjectdrug effects
dc.subjecthippocampus
dc.subjectmetabolism
dc.subjectnociception
dc.subjectpain
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrat
dc.subjectseptum nucleus
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectBicuculline
dc.subjectFormaldehyde
dc.subjectGABAergic Neurons
dc.subjectGyrus Cinguli
dc.subjectHippocampus
dc.subjectNociception
dc.subjectPain
dc.subjectRats
dc.subjectReceptors, GABA-A
dc.subjectSeptal Nuclei
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.1038/srep15419
dc.description.sourcetitleScientific Reports
dc.description.volume5
dc.description.page15419
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