Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep16252
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dc.titleTrends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
dc.contributor.authorBhoo-Pathy, N
dc.contributor.authorVerkooijen, H.M
dc.contributor.authorTan, E.-Y
dc.contributor.authorMiao, H
dc.contributor.authorTaib, N.A.M
dc.contributor.authorBrand, J.S
dc.contributor.authorDent, R.A
dc.contributor.authorSee, M.-H
dc.contributor.authorSubramaniam, S
dc.contributor.authorChan, P
dc.contributor.authorLee, S.-C
dc.contributor.authorHartman, M
dc.contributor.authorYip, C.-H
dc.date.accessioned2020-09-10T01:49:00Z
dc.date.available2020-09-10T01:49:00Z
dc.date.issued2015
dc.identifier.citationBhoo-Pathy, N, Verkooijen, H.M, Tan, E.-Y, Miao, H, Taib, N.A.M, Brand, J.S, Dent, R.A, See, M.-H, Subramaniam, S, Chan, P, Lee, S.-C, Hartman, M, Yip, C.-H (2015). Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting. Scientific Reports 5 : 16252. ScholarBank@NUS Repository. https://doi.org/10.1038/srep16252
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175472
dc.description.abstractUp to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in patient's demography, tumor characteristics, tumor burden, and treatment on survival trend were examined. Patients with de novo metastatic breast cancer from three hospitals in Malaysia and Singapore (N = 856) were grouped by year of diagnosis: 1996-2000, 2001-2005 and 2006-2010. Step-wise multivariable Poisson regression was used to estimate the contribution of above-mentioned factors on the survival trend. Proportions of patients presenting with metastatic breast cancer were 10% in 1996-2000, 7% in 2001-2005, and 9% in 2006-2010. Patients in 2006-2010 were significantly older, appeared to have higher disease burden, and received more chemotherapy, endocrine therapy, and surgery of primary tumor. The three-year relative survival in the above periods were 20.6% (95% CI: 13.9%-28.2%), 28.8% (95% CI: 23.4%-34.2%), and 33.6% (95% CI: 28.8%-38.5%), respectively. Adjustment for treatment considerably attenuated the relative excess risk of mortality in recent years, compared to other factors. Substantial improvements in survival were observed in patients with de novo metastatic breast cancer in this study.
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectAsian continental ancestry group
dc.subjectbreast tumor
dc.subjectfemale
dc.subjecthuman
dc.subjectMalaysia
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectpathology
dc.subjectphysiology
dc.subjectprognosis
dc.subjecttumor volume
dc.subjectAsian Continental Ancestry Group
dc.subjectBreast Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectMalaysia
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectTumor Burden
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.1038/srep16252
dc.description.sourcetitleScientific Reports
dc.description.volume5
dc.description.page16252
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