Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep16252
Title: Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
Authors: Bhoo-Pathy, N
Verkooijen, H.M 
Tan, E.-Y
Miao, H 
Taib, N.A.M
Brand, J.S
Dent, R.A 
See, M.-H
Subramaniam, S
Chan, P 
Lee, S.-C
Hartman, M 
Yip, C.-H
Keywords: Asian continental ancestry group
breast tumor
female
human
Malaysia
middle aged
mortality
pathology
physiology
prognosis
tumor volume
Asian Continental Ancestry Group
Breast Neoplasms
Female
Humans
Malaysia
Middle Aged
Prognosis
Tumor Burden
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Bhoo-Pathy, N, Verkooijen, H.M, Tan, E.-Y, Miao, H, Taib, N.A.M, Brand, J.S, Dent, R.A, See, M.-H, Subramaniam, S, Chan, P, Lee, S.-C, Hartman, M, Yip, C.-H (2015). Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting. Scientific Reports 5 : 16252. ScholarBank@NUS Repository. https://doi.org/10.1038/srep16252
Abstract: Up to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in patient's demography, tumor characteristics, tumor burden, and treatment on survival trend were examined. Patients with de novo metastatic breast cancer from three hospitals in Malaysia and Singapore (N = 856) were grouped by year of diagnosis: 1996-2000, 2001-2005 and 2006-2010. Step-wise multivariable Poisson regression was used to estimate the contribution of above-mentioned factors on the survival trend. Proportions of patients presenting with metastatic breast cancer were 10% in 1996-2000, 7% in 2001-2005, and 9% in 2006-2010. Patients in 2006-2010 were significantly older, appeared to have higher disease burden, and received more chemotherapy, endocrine therapy, and surgery of primary tumor. The three-year relative survival in the above periods were 20.6% (95% CI: 13.9%-28.2%), 28.8% (95% CI: 23.4%-34.2%), and 33.6% (95% CI: 28.8%-38.5%), respectively. Adjustment for treatment considerably attenuated the relative excess risk of mortality in recent years, compared to other factors. Substantial improvements in survival were observed in patients with de novo metastatic breast cancer in this study.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175472
ISSN: 20452322
DOI: 10.1038/srep16252
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_srep16252.pdf527.92 kBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.