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Title: A qualitative study on Singaporean women's views towards breast cancer screening and Single Nucleotide Polymorphisms (SNPs) gene testing to guide personalised screening strategies
Authors: Wong, X.Y
Chong, K.J
van Til, J.A
Wee, H.L 
Keywords: adult
breast cancer
cancer risk
cancer screening
cancer susceptibility
clinical article
controlled study
diagnostic accuracy
genetic screening
health care cost
image analysis
patient attitude
patient safety
personal experience
qualitative research
single nucleotide polymorphism
attitude to health
breast tumor
early cancer diagnosis
genetic screening
information processing
middle aged
patient attitude
personalized medicine
Breast Neoplasms
Early Detection of Cancer
Focus Groups
Genetic Testing
Health Knowledge, Attitudes, Practice
Middle Aged
Patient Acceptance of Health Care
Polymorphism, Single Nucleotide
Precision Medicine
Qualitative Research
Issue Date: 2017
Citation: Wong, X.Y, Chong, K.J, van Til, J.A, Wee, H.L (2017). A qualitative study on Singaporean women's views towards breast cancer screening and Single Nucleotide Polymorphisms (SNPs) gene testing to guide personalised screening strategies. BMC Cancer 17 (1) : 776. ScholarBank@NUS Repository.
Abstract: Background: Breast cancer is the top cancer by incidence and mortality in Singaporean women. Mammography is by far its best screening tool, but current recommended age and interval may not yield the most benefit. Recent studies have demonstrated the potential of single nucleotide polymorphisms (SNPs) to improve discriminatory accuracy of breast cancer risk assessment models. This study was conducted to understand Singaporean women's views towards breast cancer screening and SNPs gene testing to guide personalised screening strategies. Methods: Focus group discussions were conducted among English-speaking women (n = 27) between 40 to 65 years old, both current and lapsed mammogram users. Women were divided into four groups based on age and mammogram usage. Discussions about breast cancer and screening experience, as well as perception and attitude towards SNPs gene testing were conducted by an experienced moderator. Women were also asked for factors that will influence their uptake of the test. Transcripts were analysed using thematic analysis to captured similarities and differences in views expressed. Results: Barriers to repeat mammogram attendance include laziness to make appointment and painful and uncomfortable screening process. However, the underlying reason may be low perceived susceptibility to breast cancer. Facilitators to repeat mammogram attendance include ease of making appointment and timely reminders. Women were generally receptive towards SNPs gene testing, but required information on accuracy, cost, invasiveness, and side effects before they decide whether to go for it. Other factors include waiting time for results and frequency interval. On average, women gave a rating of 7.5 (range 5 to 10) when asked how likely they will go for the test. Conclusion: Addressing concerns such as pain and discomfort during mammogram, providing timely reminders and debunking breast cancer myths can help to improve screening uptake. Women demonstrated a spectrum of responses towards a novel test like SNPs gene testing, but need more information to make an informed decision. Future public health education on predictive genetic testing should adequately address both benefits and risks. Findings from this study is used to inform a discrete choice experiment to empirically quantify women preferences and willingness-to-pay for SNPs gene testing. © 2017 The Author(s).
Source Title: BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/s12885-017-3781-8
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