Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/17537
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dc.titleIn vivo and in vitro study on potential combination therapy of COL-3 and tamoxifen in breast cancer: a pilot study
dc.contributor.authorZHENG LIN
dc.date.accessioned2010-07-13T18:00:29Z
dc.date.available2010-07-13T18:00:29Z
dc.date.issued2007-02-05
dc.identifier.citationZHENG LIN (2007-02-05). In vivo and in vitro study on potential combination therapy of COL-3 and tamoxifen in breast cancer: a pilot study. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/17537
dc.description.abstractThis thesis project is a preclinical study on the potential combination therapy of tamoxifen with COL-3, a matrix metalloproteinases inhibitor in breast cancer therapy. Pharmacokinetic (PK) study was performed on female rats to examine the pharmacokinetic profile of COL-3 alone, or in combination of low-dose/high-dose tamoxifen in fed/fasted rats. When fed rats were pretreated with high-dose tamoxifen before COL-3a??s oral administration, absorption of COL-3 was found extensively inhibited. In order to find evidence to support our hypothesis that food may play a role in this unexpected phenomenon in COL-3 PK profile, in vitro dissolution/diffusion study was carried out to mimic the physiological environment in gastrointestinal tract. Anti-proliferative effects of COL-3, when given alone and in the combination with tamoxifen, were evaluated in estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) breast cancer cell lines. Four different PK models were proposed and compared to characterize the PK aspect of COL-3 under various conditions.
dc.language.isoen
dc.subjecttamoxifen, COL-3, breast cancer, combination therapy, pharmacokinetics, anti-proliferative effect
dc.typeThesis
dc.contributor.departmentPHARMACY
dc.contributor.supervisorCHAN WING YUEN, ELI
dc.description.degreeMaster's
dc.description.degreeconferredMASTER OF SCIENCE (PHARMACY)
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Master's Theses (Open)

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