Please use this identifier to cite or link to this item:
Title: In vivo and in vitro study on potential combination therapy of COL-3 and tamoxifen in breast cancer: a pilot study
Authors: ZHENG LIN
Keywords: tamoxifen, COL-3, breast cancer, combination therapy, pharmacokinetics, anti-proliferative effect
Issue Date: 5-Feb-2007
Citation: ZHENG LIN (2007-02-05). In vivo and in vitro study on potential combination therapy of COL-3 and tamoxifen in breast cancer: a pilot study. ScholarBank@NUS Repository.
Abstract: This thesis project is a preclinical study on the potential combination therapy of tamoxifen with COL-3, a matrix metalloproteinases inhibitor in breast cancer therapy. Pharmacokinetic (PK) study was performed on female rats to examine the pharmacokinetic profile of COL-3 alone, or in combination of low-dose/high-dose tamoxifen in fed/fasted rats. When fed rats were pretreated with high-dose tamoxifen before COL-3a??s oral administration, absorption of COL-3 was found extensively inhibited. In order to find evidence to support our hypothesis that food may play a role in this unexpected phenomenon in COL-3 PK profile, in vitro dissolution/diffusion study was carried out to mimic the physiological environment in gastrointestinal tract. Anti-proliferative effects of COL-3, when given alone and in the combination with tamoxifen, were evaluated in estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) breast cancer cell lines. Four different PK models were proposed and compared to characterize the PK aspect of COL-3 under various conditions.
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
01_title page.pdf14.54 kBAdobe PDF


02_table of contents.pdf110.88 kBAdobe PDF


03_main body of thesis.pdf1.74 MBAdobe PDF



Page view(s)

checked on May 22, 2019


checked on May 22, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.