Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphar.2018.01282
Title: Annexins in influenza virus replication and pathogenesis
Authors: Ampomah, P.B
Kong, W.T 
Zharkova, O 
Chua, S.C.J.H
Samy, R.P 
Lim, L.H.K 
Keywords: annexin
calphobindin II
cytokine
formylpeptide receptor
lipocortin 1
lipocortin 2
lipocortin 5
phospholipase A2
protein ANXA1
protein FPR2
unclassified drug
cytokine release
human
influenza A
Influenza A virus
nonhuman
protein binding
protein expression
protein family
protein function
protein phosphorylation
protein secretion
regulatory mechanism
respiratory tract inflammation
Review
signal transduction
virus pathogenesis
virus replication
Issue Date: 2018
Publisher: FRONTIERS MEDIA SA
Citation: Ampomah, P.B, Kong, W.T, Zharkova, O, Chua, S.C.J.H, Samy, R.P, Lim, L.H.K (2018). Annexins in influenza virus replication and pathogenesis. Frontiers in Pharmacology 9 (NOV) : 1282. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2018.01282
Abstract: Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome. Treatment of IAV infections is complicated because the virus can evade host immunity through antigenic drifts and antigenic shifts, to establish infections making new treatment options desirable. Annexins (ANXs) are a family of calcium and phospholipid binding proteins with immunomodulatory roles in viral infections, lung injury, and inflammation. A current understanding of the role of ANXs in modulating IAV infection and host responses will enable the future development of more effective antiviral therapies. This review presents a comprehensive understanding of the advances made in the field of ANXs, in particular, ANXA1 and IAV research and highlights the importance of ANXs as a suitable target for IAV therapy. © 2018 Ampomah, Kong, Zharkova, Chua, Perumal Samy and Lim.
Source Title: Frontiers in Pharmacology
URI: https://scholarbank.nus.edu.sg/handle/10635/175355
ISSN: 16639812
DOI: 10.3389/fphar.2018.01282
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