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https://doi.org/10.1039/c6cc00095a
| Title: | A highly selective fluorogenic probe for the detection and: In vivo imaging of Cu/Zn superoxide dismutase | Authors: | Zhang, L Er, J.C Jiang, H Li, X Luo, Z Ramezani, T Feng, Y Tang, M.K Chang, Y.-T Vendrell, M |
Keywords: | aniline benzylamine derivative copper zinc superoxide dismutase fluorine triazole copper zinc superoxide dismutase fluorescent dye animal experiment animal model Article cell viability assay chemical structure controlled study cytotoxicity enzyme activity fibroblast fluorescence human hydrogen bond hydrophobicity imaging in vitro study in vivo study inflammation limit of detection macromolecule mechanical torsion nonhuman nucleophilicity quantitative analysis quantum yield reverse transcription polymerase chain reaction substitution reaction synthesis upregulation viscosity zebra fish chemistry metabolism molecular imaging Fluorescent Dyes Molecular Imaging Molecular Structure Superoxide Dismutase-1 |
Issue Date: | 2016 | Publisher: | Royal Society of Chemistry | Citation: | Zhang, L, Er, J.C, Jiang, H, Li, X, Luo, Z, Ramezani, T, Feng, Y, Tang, M.K, Chang, Y.-T, Vendrell, M (2016). A highly selective fluorogenic probe for the detection and: In vivo imaging of Cu/Zn superoxide dismutase. Chemical Communications 52 (58) : 9093-9096. ScholarBank@NUS Repository. https://doi.org/10.1039/c6cc00095a | Abstract: | Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders. © 2016 The Royal Society of Chemistry. | Source Title: | Chemical Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/175270 | ISSN: | 1359-7345 | DOI: | 10.1039/c6cc00095a |
| Appears in Collections: | Staff Publications Elements |
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