Please use this identifier to cite or link to this item: https://doi.org/10.1158/0008-5472.CAN-15-2658
Title: Membrane IL1? inhibits the development of hepatocellular carcinoma via promoting T- and NK-cell activation
Authors: Lin, D
Lei, L
Liu, Y
Zhang, Y
Hu, B
Bao, G
Song, Y
Jin, Z
Liu, C
Mei, Y 
Sandikin, D
Wu, Y
Zhao, L
Yu, X
Liu, H 
Keywords: interleukin 1alpha
interleukin 1alpha
animal cell
animal experiment
animal model
Article
cancer growth
CD8+ T lymphocyte
confocal microscopy
controlled study
cytokine production
homeostasis
human
human cell
hydrodynamics
hydrodynamics based transfection
immune response
immunostimulation
liver cell carcinoma
lymphocyte activation
male
mouse
natural killer cell
nonhuman
plasmid
priority journal
protein analysis
protein depletion
protein expression
protein function
protein secretion
short tandem repeat
signal transduction
T lymphocyte
animal
apoptosis
C57BL mouse
cell membrane
cell proliferation
cytotoxicity
enzyme immunoassay
experimental liver neoplasm
immunology
liver cell carcinoma
lymphocyte activation
metabolism
natural killer cell
pathology
T lymphocyte
tumor cell culture
Western blotting
Animals
Apoptosis
Blotting, Western
Carcinoma, Hepatocellular
Cell Membrane
Cell Proliferation
Cytotoxicity, Immunologic
Immunoenzyme Techniques
Interleukin-1alpha
Killer Cells, Natural
Liver Neoplasms, Experimental
Lymphocyte Activation
Male
Mice
Mice, Inbred C57BL
T-Lymphocytes
Tumor Cells, Cultured
Issue Date: 2016
Publisher: American Association for Cancer Research Inc.
Citation: Lin, D, Lei, L, Liu, Y, Zhang, Y, Hu, B, Bao, G, Song, Y, Jin, Z, Liu, C, Mei, Y, Sandikin, D, Wu, Y, Zhao, L, Yu, X, Liu, H (2016). Membrane IL1? inhibits the development of hepatocellular carcinoma via promoting T- and NK-cell activation. Cancer Research 76 (11) : 3179-3188. ScholarBank@NUS Repository. https://doi.org/10.1158/0008-5472.CAN-15-2658
Abstract: Hepatocellular carcinoma is a worldwide health problem with limited treatment options and poor prognosis. Inflammation associated with liver injury and hepatocyte regeneration can lead to fibrosis, cirrhosis, and eventually, hepatocellular carcinoma. IL1? is one of the most important inflammatory cytokines involved in inflammation and tumor development. IL1? presents as multiple forms in vivo, including precursor, propiece, membrane, and secreted forms, and their functions have been thought to be different. The role of membrane IL1? in hepatocellular carcinoma tumorigenesis is still not clear. Here, we examined the functions of membrane IL1? in murine hepatocellular carcinoma models. We found that membrane IL1? potently inhibited hepatocellular carcinoma tumor growth. Further studies showed that membrane IL1? promoted T- and natural killer (NK)-cell activation in vivo. IFN? production by CD8+ T and NK cells was also increased as a result of membrane IL1? expression. Moreover, the cytotoxicity of the CTL and NK cells was also enhanced by membrane IL1? expression. Furthermore, in vitro studies demonstrated that membrane IL1? could directly activate T cells and NK cells in a cell contact-dependent manner. Conversely, depletion of both CD8+ T and NK cells suppressed the antitumor activity of membrane IL1?. Our studies demonstrated that membrane IL1? could promote antitumor immune responses through activation of T and NK cells. Thus, our findings provide new insights of IL1? functions during hepatocellular carcinoma development. ©2016 AACR.
Source Title: Cancer Research
URI: https://scholarbank.nus.edu.sg/handle/10635/175253
ISSN: 0008-5472
DOI: 10.1158/0008-5472.CAN-15-2658
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