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https://doi.org/10.3390/s16091543
Title: | Biomimetic precapillary flow patterns for enhancing blood plasma separation: A preliminary study | Authors: | Namgung B. Tan J.K.S. Wong P.A. Park S.-Y. Leo H.L. Kim S. |
Keywords: | Bifurcation (mathematics) Biomimetics Hemodynamics Blood-plasma separation Cell-free High purity Hydrodynamic separations In-vivo Physiological levels Plasma separation Plasma skimming Microfluidics |
Issue Date: | 2016 | Publisher: | MDPI AG | Citation: | Namgung B., Tan J.K.S., Wong P.A., Park S.-Y., Leo H.L., Kim S. (2016). Biomimetic precapillary flow patterns for enhancing blood plasma separation: A preliminary study. Sensors (Switzerland) 16 (9) : 1543. ScholarBank@NUS Repository. https://doi.org/10.3390/s16091543 | Abstract: | In this study, a biomimetic microfluidic plasma separation device is discussed. The design of the device drew inspiration from in vivo observations of enhanced cell-free layer (CFL) formation downstream of vascular bifurcations. The working principle for the plasma separation was based on the plasma skimming effect in an arteriolar bifurcation, which is modulated by CFL formation. The enhancement of the CFL width was achieved by a local hematocrit reduction near the collection channel by creating an uneven hematocrit distribution at the bifurcation of the channel. The device demonstrated a high purity of separation (~99. 9%) at physiological levels of hematocrit (~40%). © 2016 by the authors; licensee MDPI, Basel, Switzerland. | Source Title: | Sensors (Switzerland) | URI: | https://scholarbank.nus.edu.sg/handle/10635/175251 | ISSN: | 1424-8220 | DOI: | 10.3390/s16091543 |
Appears in Collections: | Staff Publications Elements |
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