Please use this identifier to cite or link to this item: https://doi.org/10.1186/s11658-016-0028-7
Title: Framework to function: Mechanosensitive regulators of gene transcription
Authors: Finch-Edmondson, M 
Sudol, M 
Keywords: alpha smooth muscle actin
cytoskeleton protein
myocardin related transcription factor
myocardin related transcription factor A
myocardin related transcription factor B
protein
serum response factor
TAZ protein
transcription factor
unclassified drug
yes associated protein
actin
myocardin
nuclear protein
transactivator protein
transcription factor
alpha SMA gene
biophysics
cell differentiation
cell interaction
cell migration
cell proliferation
cell survival
cytoplasm
epithelial mesenchymal transition
fibrosis
gene activation
gene expression
gene targeting
genetic transcription
human
malignant neoplasm
molecular dynamics
MRTF gene
nonhuman
nuclear localization signal
protein structure
regulator gene
Review
SRF gene
TAZ gene
YAP gene
animal
mechanotransduction
Actins
Animals
Epithelial-Mesenchymal Transition
Humans
Mechanotransduction, Cellular
Nuclear Proteins
Trans-Activators
Transcription Factors
Transcription, Genetic
Issue Date: 2016
Publisher: BioMed Central Ltd.
Citation: Finch-Edmondson, M, Sudol, M (2016). Framework to function: Mechanosensitive regulators of gene transcription. Cellular and Molecular Biology Letters 21 (1) : 28. ScholarBank@NUS Repository. https://doi.org/10.1186/s11658-016-0028-7
Abstract: Mechanobiology has shifted our understanding of fundamental cellular and physiological functions. Changes to the stiffness of the extracellular matrix, cell rigidity, or shape of the cell environment were considered in the past to be a consequence of aging or pathological processes. We now understand that these factors can actually be causative biological mediators of cell growth to control organ size. Mechanical cues are known to trigger a relatively fast translocation of specific transcriptional co-factors such as MRTFs, YAP and TAZ from the cytoplasm to the cell nucleus to initiate discrete transcriptional programs. The focus of this review is the molecular mechanisms by which biophysical stimuli that induce changes in cytoplasmic actin dynamics are communicated within cells to elicit gene-specific transcription via nuclear localisation or activation of specialized transcription factors, namely MRTFs and the Hippo pathway effectors YAP and TAZ. We propose here that MRTFs, YAP and TAZ closely collaborate as mechano-effectors. © 2016 The Author(s).
Source Title: Cellular and Molecular Biology Letters
URI: https://scholarbank.nus.edu.sg/handle/10635/175240
ISSN: 1425-8153
DOI: 10.1186/s11658-016-0028-7
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