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Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.02342-16
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dc.titleMissense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis
dc.contributor.authorYee, M
dc.contributor.authorGopal, P
dc.contributor.authorDick, T
dc.date.accessioned2020-09-09T06:26:53Z
dc.date.available2020-09-09T06:26:53Z
dc.date.issued2017
dc.identifier.citationYee, M, Gopal, P, Dick, T (2017). Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 61 (2) : e02342. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02342-16
dc.identifier.issn0066-4804
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175236
dc.description.abstractPreviously, we showed that mutations in Mycobacterium tuberculosis panD, involved in coenzyme A biosynthesis, cause resistance against pyrazinoic acid, the bioactive component of the prodrug pyrazinamide. To identify additional resistance mechanisms, we isolated mutants resistant against pyrazinoic acid and subjected panD wild-type strains to whole-genome sequencing. Eight of the nine resistant strains harbored missense mutations in the unfoldase ClpC1 associated with the caseinolytic protease complex. © 2017 Yee et al.
dc.publisherAmerican Society for Microbiology
dc.sourceUnpaywall 20200831
dc.subjectclpc1 protein
dc.subjectgenomic DNA
dc.subjectisoniazid
dc.subjectmessenger RNA
dc.subjectproteasome
dc.subjectprotein
dc.subjectpyrazinamide
dc.subjectpyrazinoic acid
dc.subjectrifampicin
dc.subjectunclassified drug
dc.subjectpyrazinamide
dc.subjecttuberculostatic agent
dc.subjectamino acid substitution
dc.subjectamino terminal sequence
dc.subjectArticle
dc.subjectbacterium culture
dc.subjectbroth dilution
dc.subjectcell suspension
dc.subjectcolony formation
dc.subjectcryopreservation
dc.subjectDNA extraction
dc.subjecthydrolysis
dc.subjectloss of function mutation
dc.subjectmissense mutation
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectsingle nucleotide polymorphism
dc.subjectspontaneous mutation
dc.subjectwhole genome sequencing
dc.subjectanalogs and derivatives
dc.subjectantibiotic resistance
dc.subjectdrug effects
dc.subjectgenetics
dc.subjectmicrobial sensitivity test
dc.subjectmissense mutation
dc.subjectmutation
dc.subjectMycobacterium tuberculosis
dc.subjectAntitubercular Agents
dc.subjectDrug Resistance, Bacterial
dc.subjectMicrobial Sensitivity Tests
dc.subjectMutation
dc.subjectMutation, Missense
dc.subjectMycobacterium tuberculosis
dc.subjectPyrazinamide
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.doi10.1128/AAC.02342-16
dc.description.sourcetitleAntimicrobial Agents and Chemotherapy
dc.description.volume61
dc.description.issue2
dc.description.pagee02342
dc.published.statePublished
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