Please use this identifier to cite or link to this item: https://doi.org/10.3390/nu9070683
Title: Meat and seafood consumption in relation to plasma metabolic profiles in a Chinese population: A combined untargeted and targeted metabolomics study
Authors: Lu, Y 
Zou, L 
Su, J
Tai, E 
Whitton, C 
van Dam, R.M 
Ong, C.N 
Keywords: 3 carboxy 4 methyl 5 propyl 2 furanpropanoic acid
C reactive protein
cholesterol
creatinine
essential amino acid
glucose
insulin
phosphatidylethanolamine
polyunsaturated fatty acid
unclassified drug
amino acid
biological marker
unsaturated fatty acid
adult
alcohol consumption
Article
blood analysis
blood level
Chinese
egg
feeding behavior
female
fish
food frequency questionnaire
food intake
liquid chromatography-mass spectrometry
male
mass fragmentography
meat
metabolite
metabolomics
plasma metabolite level
portion size
poultry product
red meat
sea food
shellfish
soy food
animal
Asian continental ancestry group
blood
diet
human
metabolome
metabolomics
middle aged
Singapore
Adult
Amino Acids
Animals
Asian Continental Ancestry Group
Biomarkers
Diet Surveys
Fatty Acids, Unsaturated
Feeding Behavior
Female
Humans
Male
Meat
Metabolome
Metabolomics
Middle Aged
Seafood
Singapore
Issue Date: 2017
Citation: Lu, Y, Zou, L, Su, J, Tai, E, Whitton, C, van Dam, R.M, Ong, C.N (2017). Meat and seafood consumption in relation to plasma metabolic profiles in a Chinese population: A combined untargeted and targeted metabolomics study. Nutrients 9 (7) : 683. ScholarBank@NUS Repository. https://doi.org/10.3390/nu9070683
Abstract: We examined the relationship between different patterns of meat and seafood consumption and plasma metabolic profiles in an Asian population. We selected 270 ethnic Chinese men and women from the Singapore Prospective Study Program based on their dietary habits assessed with a validated food frequency questionnaire. Participants were divided into four subgroups: high meat and high seafood (n = 60), high meat and low seafood (n = 64), low meat and high seafood (n = 60), and low meat and low seafood (n = 86) consumers. Plasma metabolites were measured using both targeted and untargeted mass spectroscopy-based analyses. A total of 42 metabolites differed significantly by dietary group. Higher concentrations of essential amino acids, polyunsaturated fatty acids, and D-glucose were found in high meat and/or seafood consumers as compared with the group with a low consumption of these animal foods. Red meat, poultry, fish, shellfish, soy products, and dairy were each correlated with at least one differential metabolite (r = -0.308 to 0.448). Some observations, such as the correlation between fish and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), confirmed previous studies. Other observations, such as the correlation between shellfish and phosphatidylethanolamine (p36:4), were novel. We also observed significant correlations between plasma metabolites and clinical characteristics, such as CMPF with fasting blood glucose (r = 0.401). These findings demonstrate a significant influence of meat and seafood consumption on metabolic profiles in the Asian population. © 2017 by the authors.
Source Title: Nutrients
URI: https://scholarbank.nus.edu.sg/handle/10635/175206
ISSN: 20726643
DOI: 10.3390/nu9070683
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