Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-01282-6
Title: A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
Authors: Pompon, J 
Morales-Vargas, R
Manuel, M
Tan, C.H
Vial, T
Tan, J.H 
Sessions, O.M 
Vasconcelos, P.D.C
Ng, L.C
Missé, D
Keywords: Aedes
animal
classification
disease transmission
human
isolation and purification
mosquito vector
saliva
time factor
transmission
virology
virus load
Zika fever
Zika virus
Aedes
Animals
Disease Transmission, Infectious
Humans
Mosquito Vectors
Saliva
Time Factors
Viral Load
Zika Virus
Zika Virus Infection
Issue Date: 2017
Citation: Pompon, J, Morales-Vargas, R, Manuel, M, Tan, C.H, Vial, T, Tan, J.H, Sessions, O.M, Vasconcelos, P.D.C, Ng, L.C, Missé, D (2017). A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia. Scientific Reports 7 (1) : 1215. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-01282-6
Abstract: Zika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. The first outbreak was recorded in Micronesia in 2007, then in French Polynesia in 2014 from which it spread to South America in 2015 and ignited a widespread epidemic. Interestingly, Zika outbreaks in Asia remained of moderate intensity although the virus is circulating. To understand these epidemiological variations, we investigated the entomological determinants of ZIKV transmission in Asia. We used oral infection of mosquitoes collected in Singapore to identify the vector species, to quantify the blood infection threshold and to compare transmissibility between an Asian ZIKV strain (H/PF13) and an American strain collected in Brazil (BE H 815744). We have confirmed the vector status of Aedes aegypti and determined that 103 pfu/ml of blood is sufficient to infect mosquitoes. We showed that only the American strain was present in the saliva 3 days post-infection, and that this strain had a 30-40% higher rate of saliva infection in Ae. aegypti from 3 to 14 days post-infection than the Asian strain. Our data suggests that American strains are more efficiently transmitted than Asian strains, which raises concerns about the introduction of American strains in Asia. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175190
ISSN: 20452322
DOI: 10.1038/s41598-017-01282-6
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