Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-01282-6
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dc.titleA Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
dc.contributor.authorPompon, J
dc.contributor.authorMorales-Vargas, R
dc.contributor.authorManuel, M
dc.contributor.authorTan, C.H
dc.contributor.authorVial, T
dc.contributor.authorTan, J.H
dc.contributor.authorSessions, O.M
dc.contributor.authorVasconcelos, P.D.C
dc.contributor.authorNg, L.C
dc.contributor.authorMissé, D
dc.date.accessioned2020-09-09T04:57:30Z
dc.date.available2020-09-09T04:57:30Z
dc.date.issued2017
dc.identifier.citationPompon, J, Morales-Vargas, R, Manuel, M, Tan, C.H, Vial, T, Tan, J.H, Sessions, O.M, Vasconcelos, P.D.C, Ng, L.C, Missé, D (2017). A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia. Scientific Reports 7 (1) : 1215. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-01282-6
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175190
dc.description.abstractZika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. The first outbreak was recorded in Micronesia in 2007, then in French Polynesia in 2014 from which it spread to South America in 2015 and ignited a widespread epidemic. Interestingly, Zika outbreaks in Asia remained of moderate intensity although the virus is circulating. To understand these epidemiological variations, we investigated the entomological determinants of ZIKV transmission in Asia. We used oral infection of mosquitoes collected in Singapore to identify the vector species, to quantify the blood infection threshold and to compare transmissibility between an Asian ZIKV strain (H/PF13) and an American strain collected in Brazil (BE H 815744). We have confirmed the vector status of Aedes aegypti and determined that 103 pfu/ml of blood is sufficient to infect mosquitoes. We showed that only the American strain was present in the saliva 3 days post-infection, and that this strain had a 30-40% higher rate of saliva infection in Ae. aegypti from 3 to 14 days post-infection than the Asian strain. Our data suggests that American strains are more efficiently transmitted than Asian strains, which raises concerns about the introduction of American strains in Asia. © 2017 The Author(s).
dc.sourceUnpaywall 20200831
dc.subjectAedes
dc.subjectanimal
dc.subjectclassification
dc.subjectdisease transmission
dc.subjecthuman
dc.subjectisolation and purification
dc.subjectmosquito vector
dc.subjectsaliva
dc.subjecttime factor
dc.subjecttransmission
dc.subjectvirology
dc.subjectvirus load
dc.subjectZika fever
dc.subjectZika virus
dc.subjectAedes
dc.subjectAnimals
dc.subjectDisease Transmission, Infectious
dc.subjectHumans
dc.subjectMosquito Vectors
dc.subjectSaliva
dc.subjectTime Factors
dc.subjectViral Load
dc.subjectZika Virus
dc.subjectZika Virus Infection
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41598-017-01282-6
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page1215
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