Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41598-017-05021-9
DC Field | Value | |
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dc.title | Effects of Aortic Valve Replacement on Severe Aortic Stenosis and Preserved Systolic Function: Systematic Review and Network Meta-analysis /692/4019/592/1540 /692/4019/592/75/591 article | |
dc.contributor.author | Zheng, Q | |
dc.contributor.author | Djohan, A.H | |
dc.contributor.author | Lim, E | |
dc.contributor.author | Ding, Z.P | |
dc.contributor.author | Ling, L.H | |
dc.contributor.author | Shi, L | |
dc.contributor.author | Chan, E.S.-Y | |
dc.contributor.author | Chin, C.W.L | |
dc.date.accessioned | 2020-09-09T04:54:52Z | |
dc.date.available | 2020-09-09T04:54:52Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Zheng, Q, Djohan, A.H, Lim, E, Ding, Z.P, Ling, L.H, Shi, L, Chan, E.S.-Y, Chin, C.W.L (2017). Effects of Aortic Valve Replacement on Severe Aortic Stenosis and Preserved Systolic Function: Systematic Review and Network Meta-analysis /692/4019/592/1540 /692/4019/592/75/591 article. Scientific Reports 7 (1) : 5092. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-05021-9 | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175182 | |
dc.description.abstract | The survival benefits of aortic valve replacement (AVR) in the different flow-gradient states of severe aortic stenosis (AS) is not known. A comprehensive search in PubMed/MEDLINE, Embase, Cochrane Library, CNKI and OpenGrey were conducted to identify studies that investigated the prognosis of severe AS (effective orifice area ?1.0 cm2) and left ventricular ejection fraction ?50%. Severe AS was stratified by mean pressure gradient [threshold of 40 mmHg; high-gradient (HG) and low-gradient (LG)] and stroke volume index [threshold of 35 ml/m2; normal-flow (NL) and low-flow (LF)]. Network meta-analysis was conducted to assess all-cause mortality among each AS sub-type with rate ratio (RR) reported. The effects of AVR on prognosis were examined using network meta-regression. In the pooled analysis (15 studies and 9,737 patients), LF states (both HG and LG) were associated with increased mortality rate (LFLG: RR 1.88; 95% CI: 1.43-2.46; LFHG: RR: 1.77; 95% CI: 1.16-2.70) compared to moderate AS; and NF states in both HG and LG had similar prognosis as moderate AS (NFLG: RR 1.11; 95% CI: 0.81-1.53; NFHG: RR 1.16; 95% CI: 0.82-1.64). AVR conferred different survival benefits: it was most effective in NFHG (RR with AVR /RR without AVR : 0.43; 95% CI: 0.22-0.82) and least in LFLG (RR with AVR /RR without AVR : 1.19; 95% CI: 0.74-1.94). © 2017 The Author(s). | |
dc.source | Unpaywall 20200831 | |
dc.subject | aged | |
dc.subject | aortic valve | |
dc.subject | aortic valve stenosis | |
dc.subject | coronary artery blood flow | |
dc.subject | female | |
dc.subject | heart stroke volume | |
dc.subject | human | |
dc.subject | male | |
dc.subject | meta analysis | |
dc.subject | middle aged | |
dc.subject | mortality | |
dc.subject | pathophysiology | |
dc.subject | physiology | |
dc.subject | probability | |
dc.subject | prognosis | |
dc.subject | publishing | |
dc.subject | survival analysis | |
dc.subject | systole | |
dc.subject | transcatheter aortic valve implantation | |
dc.subject | very elderly | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Aortic Valve | |
dc.subject | Aortic Valve Stenosis | |
dc.subject | Coronary Circulation | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Probability | |
dc.subject | Prognosis | |
dc.subject | Publication Bias | |
dc.subject | Stroke Volume | |
dc.subject | Survival Analysis | |
dc.subject | Systole | |
dc.subject | Transcatheter Aortic Valve Replacement | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/s41598-017-05021-9 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 7 | |
dc.description.issue | 1 | |
dc.description.page | 5092 | |
Appears in Collections: | Elements Staff Publications |
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