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https://doi.org/10.1038/s41598-017-08466-0
Title: | Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism | Authors: | Eriksson, A Raczkowska, M Navawongse, R Choudhury, D Stewart, J.C Tang, Y.L Wang, Z Claridge-Chang, A |
Keywords: | agents interacting with transmitter, hormone or drug receptors biological marker animal dopaminergic nerve cell Drosophila drug effect energy metabolism feeding behavior gene expression gene silencing genetics male meta analysis metabolism nerve cell physiology Animals Biomarkers Dopaminergic Neurons Drosophila Energy Metabolism Feeding Behavior Gene Expression Gene Silencing Male Neurons Neurotransmitter Agents |
Issue Date: | 2017 | Citation: | Eriksson, A, Raczkowska, M, Navawongse, R, Choudhury, D, Stewart, J.C, Tang, Y.L, Wang, Z, Claridge-Chang, A (2017). Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism. Scientific Reports 7 (1) : 8839. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-08466-0 | Abstract: | Animals have evolved to maintain homeostasis in a changing external environment by adapting their internal metabolism and feeding behaviour. Metabolism and behaviour are coordinated by neuromodulation; a number of the implicated neuromodulatory systems are homologous between mammals and the vinegar fly, an important neurogenetic model. We investigated whether silencing fly neuromodulatory networks would elicit coordinated changes in feeding, behavioural activity and metabolism. We employed transgenic lines that allowed us to inhibit broad cellular sets of the dopaminergic, serotonergic, octopaminergic, tyraminergic and neuropeptide F systems. The genetically-manipulated animals were assessed for changes in their overt behavioural responses and metabolism by monitoring eleven parameters: activity; climbing ability; individual feeding; group feeding; food discovery; both fed and starved respiration; fed and starved lipid content; and fed/starved body weight. The results from these 55 experiments indicate that individual neuromodulatory system effects on feeding behaviour, motor activity and metabolism are dissociated. © 2017 The Author(s). | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/175178 | ISSN: | 20452322 | DOI: | 10.1038/s41598-017-08466-0 |
Appears in Collections: | Elements Staff Publications |
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