Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-08466-0
Title: Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
Authors: Eriksson, A
Raczkowska, M
Navawongse, R
Choudhury, D
Stewart, J.C
Tang, Y.L
Wang, Z
Claridge-Chang, A 
Keywords: agents interacting with transmitter, hormone or drug receptors
biological marker
animal
dopaminergic nerve cell
Drosophila
drug effect
energy metabolism
feeding behavior
gene expression
gene silencing
genetics
male
meta analysis
metabolism
nerve cell
physiology
Animals
Biomarkers
Dopaminergic Neurons
Drosophila
Energy Metabolism
Feeding Behavior
Gene Expression
Gene Silencing
Male
Neurons
Neurotransmitter Agents
Issue Date: 2017
Citation: Eriksson, A, Raczkowska, M, Navawongse, R, Choudhury, D, Stewart, J.C, Tang, Y.L, Wang, Z, Claridge-Chang, A (2017). Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism. Scientific Reports 7 (1) : 8839. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-08466-0
Abstract: Animals have evolved to maintain homeostasis in a changing external environment by adapting their internal metabolism and feeding behaviour. Metabolism and behaviour are coordinated by neuromodulation; a number of the implicated neuromodulatory systems are homologous between mammals and the vinegar fly, an important neurogenetic model. We investigated whether silencing fly neuromodulatory networks would elicit coordinated changes in feeding, behavioural activity and metabolism. We employed transgenic lines that allowed us to inhibit broad cellular sets of the dopaminergic, serotonergic, octopaminergic, tyraminergic and neuropeptide F systems. The genetically-manipulated animals were assessed for changes in their overt behavioural responses and metabolism by monitoring eleven parameters: activity; climbing ability; individual feeding; group feeding; food discovery; both fed and starved respiration; fed and starved lipid content; and fed/starved body weight. The results from these 55 experiments indicate that individual neuromodulatory system effects on feeding behaviour, motor activity and metabolism are dissociated. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175178
ISSN: 20452322
DOI: 10.1038/s41598-017-08466-0
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