Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10067-017-3698-2
Title: Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus
Authors: Mak, A 
Thornhill, S.I
Lee, H.Y
Lee, B
Poidinger, M 
Connolly, J.E 
Fairhurst, A.-M 
Keywords: antigen
autoantibody
CD150 antigen
CD229 antigen
CD244 antigen
CD319 antigen
CD352 antigen
CD48 antigen
CD84 antigen
signaling lymphocytic activation molecule
signaling lymphocytic activation molecule F4 protein
unclassified drug
CD244 protein, human
signaling lymphocytic activation molecule
adult
antibody titer
antigen expression
Article
Asian
clinical article
controlled study
disease activity
human
human cell
immunological tolerance
monocyte
natural killer cell
polymorphonuclear cell
priority journal
protein expression
systemic lupus erythematosus
T lymphocyte
thrombocyte
female
male
metabolism
monocyte
systemic lupus erythematosus
thrombocyte
Adult
Blood Platelets
Female
Humans
Lupus Erythematosus, Systemic
Male
Monocytes
Signaling Lymphocytic Activation Molecule Family
Issue Date: 2018
Publisher: Springer London
Citation: Mak, A, Thornhill, S.I, Lee, H.Y, Lee, B, Poidinger, M, Connolly, J.E, Fairhurst, A.-M (2018). Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus. Clinical Rheumatology 37 (3) : 811-816. ScholarBank@NUS Repository. https://doi.org/10.1007/s10067-017-3698-2
Abstract: The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE). Since previous investigations on CD244 expression have focussed on NK and T cells, the aim of this study was to evaluate the surface expression of major SLAMF members across monocytes and polymorphonuclear cells in an Asian SLE cohort and explore their potential associations with SLE-related disease activity and autoantibodies. Thirty-nine SLE patients and twenty-nine healthy controls (HC) were evaluated for the expression of CD150, CD84, CD229, CD48, CD244, CD352 and CD319. We determined a significantly lower expression of CD244 on monocytes in SLE patients compared to HC. Furthermore, monocyte CD244 expression was negatively associated with several serum autoantibody titres. Our findings suggest that this molecule plays an important role in immune tolerance mechanisms and should be investigated further. © 2017, The Author(s).
Source Title: Clinical Rheumatology
URI: https://scholarbank.nus.edu.sg/handle/10635/175125
ISSN: 0770-3198
DOI: 10.1007/s10067-017-3698-2
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