Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41388-017-0038-6
DC Field | Value | |
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dc.title | GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers | |
dc.contributor.author | Rasheed, S.A.K | |
dc.contributor.author | Leong, H.S | |
dc.contributor.author | Lakshmanan, M | |
dc.contributor.author | Raju, A | |
dc.contributor.author | Dadlani, D | |
dc.contributor.author | Chong, F.-T | |
dc.contributor.author | Shannon, N.B | |
dc.contributor.author | Rajarethinam, R | |
dc.contributor.author | Skanthakumar, T | |
dc.contributor.author | Tan, E.Y | |
dc.contributor.author | Hwang, J.S.G | |
dc.contributor.author | Lim, K.H | |
dc.contributor.author | Tan, D.S.-W | |
dc.contributor.author | Ceppi, P | |
dc.contributor.author | Wang, M | |
dc.contributor.author | Tergaonkar, V | |
dc.contributor.author | Casey, P.J | |
dc.contributor.author | Iyer, N.G | |
dc.date.accessioned | 2020-09-09T04:10:54Z | |
dc.date.available | 2020-09-09T04:10:54Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Rasheed, S.A.K, Leong, H.S, Lakshmanan, M, Raju, A, Dadlani, D, Chong, F.-T, Shannon, N.B, Rajarethinam, R, Skanthakumar, T, Tan, E.Y, Hwang, J.S.G, Lim, K.H, Tan, D.S.-W, Ceppi, P, Wang, M, Tergaonkar, V, Casey, P.J, Iyer, N.G (2018). GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. Oncogene 37 (10) : 1340-1353. ScholarBank@NUS Repository. https://doi.org/10.1038/s41388-017-0038-6 | |
dc.identifier.issn | 0950-9232 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175123 | |
dc.description.abstract | Treatment failure in solid tumors occurs due to the survival of specific subpopulations of cells that possess tumor-initiating (TIC) phenotypes. Studies have implicated G protein-coupled-receptors (GPCRs) in cancer progression and the acquisition of TIC phenotypes. Many of the implicated GPCRs signal through the G protein GNA13. In this study, we demonstrate that GNA13 is upregulated in many solid tumors and impacts survival and metastases in patients. GNA13 levels modulate drug resistance and TIC-like phenotypes in patient-derived head and neck squamous cell carcinoma (HNSCC) cells in vitro and in vivo. Blockade of GNA13 expression, or of select downstream pathways, using small-molecule inhibitors abrogates GNA13-induced TIC phenotypes, rendering cells vulnerable to standard-of-care cytotoxic therapies. Taken together, these data indicate that GNA13 expression is a potential prognostic biomarker for tumor progression, and that interfering with GNA13-induced signaling provides a novel strategy to block TICs and drug resistance in HNSCCs. © 2017 The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Unpaywall 20200831 | |
dc.subject | antineoplastic agent | |
dc.subject | cisplatin | |
dc.subject | cytotoxic agent | |
dc.subject | GNA13 protein | |
dc.subject | GNA13 protein inhibitor | |
dc.subject | guanine nucleotide binding protein | |
dc.subject | protein inhibitor | |
dc.subject | tumor marker | |
dc.subject | unclassified drug | |
dc.subject | antineoplastic agent | |
dc.subject | guanine nucleotide binding protein alpha subunit | |
dc.subject | tumor marker | |
dc.subject | animal cell | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | animal tissue | |
dc.subject | Article | |
dc.subject | cancer growth | |
dc.subject | cancer patient | |
dc.subject | cancer prognosis | |
dc.subject | cancer resistance | |
dc.subject | cancer survival | |
dc.subject | carcinoma cell | |
dc.subject | controlled study | |
dc.subject | head and neck squamous cell carcinoma | |
dc.subject | human | |
dc.subject | human cell | |
dc.subject | in vitro study | |
dc.subject | in vivo study | |
dc.subject | metastasis | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | phenotype | |
dc.subject | priority journal | |
dc.subject | protein expression | |
dc.subject | protein function | |
dc.subject | randomized controlled trial | |
dc.subject | signal transduction | |
dc.subject | solid malignant neoplasm | |
dc.subject | tumor initiating phenotype | |
dc.subject | upregulation | |
dc.subject | animal | |
dc.subject | cell proliferation | |
dc.subject | cell transformation | |
dc.subject | drug effect | |
dc.subject | drug resistance | |
dc.subject | drug therapy | |
dc.subject | gene expression regulation | |
dc.subject | genetics | |
dc.subject | nonobese diabetic mouse | |
dc.subject | pathology | |
dc.subject | phenotype | |
dc.subject | SCID mouse | |
dc.subject | tumor cell culture | |
dc.subject | Animals | |
dc.subject | Antineoplastic Agents | |
dc.subject | Biomarkers, Tumor | |
dc.subject | Cell Proliferation | |
dc.subject | Cell Transformation, Neoplastic | |
dc.subject | Drug Resistance, Neoplasm | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | GTP-Binding Protein alpha Subunits | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Mice, Inbred NOD | |
dc.subject | Mice, SCID | |
dc.subject | Phenotype | |
dc.subject | Signal Transduction | |
dc.subject | Squamous Cell Carcinoma of Head and Neck | |
dc.subject | Tumor Cells, Cultured | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/s41388-017-0038-6 | |
dc.description.sourcetitle | Oncogene | |
dc.description.volume | 37 | |
dc.description.issue | 10 | |
dc.description.page | 1340-1353 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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