Please use this identifier to cite or link to this item: https://doi.org/10.3201/eid2408.171883
Title: Distinguishing zika and dengue viruses through simple clinical assessment, Singapore
Authors: Yan, G
Pang, L 
Cook, A.R 
Ho, H.J
Win, M.S
Khoo, A.L
Wong, J.G.X
Lee, C.K
Yan, B
Jureen, R 
Ho, S.S
Lye, D.C 
Tambyah, P.A 
Leo, Y.S
Fisher, D 
Oon, J 
Bagdasarian, N 
Chow, A
Smitasin, N 
Chai, L.Y.A 
Keywords: alanine aminotransferase
aspartate aminotransferase
nonstructural protein 1
virus RNA
adult
aged
arthralgia
Article
biochemical analysis
blood analysis
case control study
clinical assessment
cohort analysis
conjunctivitis
dengue
Dengue virus
diagnostic accuracy
female
fever
headache
human
major clinical study
male
monocyte count
monocytosis
myalgia
nonhuman
platelet count
predictive value
receiver operating characteristic
reverse transcription polymerase chain reaction
sensitivity and specificity
Singapore
symptomatology
urinalysis
validation process
Youden index
Zika fever
Zika virus
Aedes
animal
dengue
Dengue virus
differential diagnosis
fever
leukocyte count
middle aged
mosquito vector
myalgia
pathophysiology
transmission
viral conjunctivitis
virology
Zika fever
Zika virus
Adult
Aedes
Aged
Animals
Case-Control Studies
Cohort Studies
Conjunctivitis, Viral
Dengue
Dengue Virus
Diagnosis, Differential
Female
Fever
Humans
Leukocyte Count
Male
Middle Aged
Mosquito Vectors
Myalgia
Platelet Count
ROC Curve
Singapore
Zika Virus
Zika Virus Infection
Issue Date: 2018
Publisher: Centers for Disease Control and Prevention (CDC)
Citation: Yan, G, Pang, L, Cook, A.R, Ho, H.J, Win, M.S, Khoo, A.L, Wong, J.G.X, Lee, C.K, Yan, B, Jureen, R, Ho, S.S, Lye, D.C, Tambyah, P.A, Leo, Y.S, Fisher, D, Oon, J, Bagdasarian, N, Chow, A, Smitasin, N, Chai, L.Y.A (2018). Distinguishing zika and dengue viruses through simple clinical assessment, Singapore. Emerging Infectious Diseases 24 (8) : 1565-1568. ScholarBank@NUS Repository. https://doi.org/10.3201/eid2408.171883
Abstract: Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case–control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses. © 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
Source Title: Emerging Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/175107
ISSN: 1080-6040
DOI: 10.3201/eid2408.171883
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