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https://doi.org/10.1038/s41598-017-08276-4
Title: | Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study | Authors: | Ting, D.S.W Yanagi, Y Agrawal, R Teo, H.Y Seen, S Yeo, I.Y.S Mathur, R Chan, C.M Lee, S.Y Wong, E.Y.M Wong, D Wong, T.Y Cheung, G.C.M |
Keywords: | aged choroid diagnostic imaging female human macular degeneration male middle aged optical coherence tomography pathology polyp procedures prospective study subretinal neovascularization time factor very elderly visual acuity Aged Aged, 80 and over Choroid Choroidal Neovascularization Female Humans Macular Degeneration Male Middle Aged Polyps Prospective Studies Time Factors Tomography, Optical Coherence Visual Acuity |
Issue Date: | 2017 | Citation: | Ting, D.S.W, Yanagi, Y, Agrawal, R, Teo, H.Y, Seen, S, Yeo, I.Y.S, Mathur, R, Chan, C.M, Lee, S.Y, Wong, E.Y.M, Wong, D, Wong, T.Y, Cheung, G.C.M (2017). Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study. Scientific Reports 7 (1) : 7868. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-08276-4 | Abstract: | Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stromal area in 118 patients with typical AMD (t-AMD) and polypoidal choroidal vasculopathy (PCV) over a 12-month period. We used spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode to measure the subfoveal choroidal thickness (CT), central retinal thickness (CRT) and choroidal vascularity index (CVI - ratio of luminal area to total choroidal area). At baseline, PCV eyes had higher CRT (471.6 µm vs 439.1 µm, p = 0.02), but comparable subfoveal CT and CVI, compared to t-AMD. Eyes with high CVI at baseline showed marked reduction in stromal area compared with eyes with average or low CVI. Over 12 months, CRT and subfoveal CT significantly decreased (p < 0.001) in both subtypes. Eyes with high baseline CVI showed significant CVI reduction from baseline to month 12 (p < 0.001), whereas eyes with average to low baseline CVI showed increase in CVI. These differences in choroidal vascularity may reflect different predominant pathogenic processes and remodeling in AMD eyes with varying spectrum. © 2017, The Author(s). | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/175086 | ISSN: | 20452322 | DOI: | 10.1038/s41598-017-08276-4 |
Appears in Collections: | Elements Staff Publications |
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