Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-08276-4
Title: Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
Authors: Ting, D.S.W
Yanagi, Y 
Agrawal, R
Teo, H.Y
Seen, S
Yeo, I.Y.S 
Mathur, R 
Chan, C.M 
Lee, S.Y 
Wong, E.Y.M 
Wong, D 
Wong, T.Y 
Cheung, G.C.M 
Keywords: aged
choroid
diagnostic imaging
female
human
macular degeneration
male
middle aged
optical coherence tomography
pathology
polyp
procedures
prospective study
subretinal neovascularization
time factor
very elderly
visual acuity
Aged
Aged, 80 and over
Choroid
Choroidal Neovascularization
Female
Humans
Macular Degeneration
Male
Middle Aged
Polyps
Prospective Studies
Time Factors
Tomography, Optical Coherence
Visual Acuity
Issue Date: 2017
Citation: Ting, D.S.W, Yanagi, Y, Agrawal, R, Teo, H.Y, Seen, S, Yeo, I.Y.S, Mathur, R, Chan, C.M, Lee, S.Y, Wong, E.Y.M, Wong, D, Wong, T.Y, Cheung, G.C.M (2017). Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study. Scientific Reports 7 (1) : 7868. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-08276-4
Abstract: Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stromal area in 118 patients with typical AMD (t-AMD) and polypoidal choroidal vasculopathy (PCV) over a 12-month period. We used spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode to measure the subfoveal choroidal thickness (CT), central retinal thickness (CRT) and choroidal vascularity index (CVI - ratio of luminal area to total choroidal area). At baseline, PCV eyes had higher CRT (471.6 µm vs 439.1 µm, p = 0.02), but comparable subfoveal CT and CVI, compared to t-AMD. Eyes with high CVI at baseline showed marked reduction in stromal area compared with eyes with average or low CVI. Over 12 months, CRT and subfoveal CT significantly decreased (p < 0.001) in both subtypes. Eyes with high baseline CVI showed significant CVI reduction from baseline to month 12 (p < 0.001), whereas eyes with average to low baseline CVI showed increase in CVI. These differences in choroidal vascularity may reflect different predominant pathogenic processes and remodeling in AMD eyes with varying spectrum. © 2017, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175086
ISSN: 20452322
DOI: 10.1038/s41598-017-08276-4
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