Please use this identifier to cite or link to this item:
https://doi.org/10.3390/jfb9010018
DC Field | Value | |
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dc.title | Modulation of osteoclast interactions with orthopaedic biomaterials | |
dc.contributor.author | Steffi, C | |
dc.contributor.author | Shi, Z | |
dc.contributor.author | Kong, C.H | |
dc.contributor.author | Wang, W | |
dc.date.accessioned | 2020-09-09T03:12:18Z | |
dc.date.available | 2020-09-09T03:12:18Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Steffi, C, Shi, Z, Kong, C.H, Wang, W (2018). Modulation of osteoclast interactions with orthopaedic biomaterials. Journal of Functional Biomaterials 9 (1) : 18. ScholarBank@NUS Repository. https://doi.org/10.3390/jfb9010018 | |
dc.identifier.issn | 20794983 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175068 | |
dc.description.abstract | Biomaterial integration in bone depends on bone remodelling at the bone-implant interface. Optimal balance of bone resorption by osteoclasts and bone deposition by osteoblasts is crucial for successful implantation, especially in orthopaedic surgery. Most studies examined osteoblast differentiation on biomaterials, yet few research has been conducted to explore the effect of different orthopaedic implants on osteoclast development. This review covers, in detail, the biology of osteoclasts, in vitro models of osteoclasts, and modulation of osteoclast activity by different implant surfaces, bio-ceramics, and polymers. Studies show that surface topography influence osteoclastogenesis. For instance, metal implants with rough surfaces enhanced osteoclast activity, while smooth surfaces resulted in poor osteoclast differentiation. In addition, surface modification of implants with anti-osteoporotic drug further decreased osteoclast activity. In bioceramics, osteoclast development depended on different chemical compositions. Strontium-incorporated bioceramics decreased osteoclast development, whereas higher concentrations of silica enhanced osteoclast activity. Differences between natural and synthetic polymers also modulated osteoclastogenesis. Physiochemical properties of implants affect osteoclast activity. Hence, understanding osteoclast biology and its response to the natural microarchitecture of bone are indispensable to design suitable implant interfaces and scaffolds, which will stimulate osteoclasts in ways similar to that of native bone. © 2018 by the authors. | |
dc.source | Unpaywall 20200831 | |
dc.subject | bioceramics | |
dc.subject | biomaterial | |
dc.subject | colony stimulating factor 1 | |
dc.subject | interleukin 1 | |
dc.subject | osteoclast differentiation factor | |
dc.subject | osteoprotegerin | |
dc.subject | polymer | |
dc.subject | silicon dioxide | |
dc.subject | strontium | |
dc.subject | transcription factor RUNX2 | |
dc.subject | tumor necrosis factor | |
dc.subject | bone mineralization | |
dc.subject | bone remodeling | |
dc.subject | cell activation | |
dc.subject | cell activity | |
dc.subject | cell differentiation | |
dc.subject | cell interaction | |
dc.subject | cell maturation | |
dc.subject | cell survival | |
dc.subject | cytokine release | |
dc.subject | human | |
dc.subject | osteoblast | |
dc.subject | osteoclast | |
dc.subject | osteoclastogenesis | |
dc.subject | osteolysis | |
dc.subject | physical chemistry | |
dc.subject | protein expression | |
dc.subject | protein protein interaction | |
dc.subject | Review | |
dc.type | Review | |
dc.contributor.department | DEPT OF ORTHOPAEDIC SURGERY | |
dc.description.doi | 10.3390/jfb9010018 | |
dc.description.sourcetitle | Journal of Functional Biomaterials | |
dc.description.volume | 9 | |
dc.description.issue | 1 | |
dc.description.page | 18 | |
Appears in Collections: | Elements Staff Publications |
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10_3390_jfb9010018.pdf | 1.66 MB | Adobe PDF | OPEN | None | View/Download |
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