Please use this identifier to cite or link to this item: https://doi.org/10.3390/jfb9010018
Title: Modulation of osteoclast interactions with orthopaedic biomaterials
Authors: Steffi, C 
Shi, Z 
Kong, C.H
Wang, W 
Keywords: bioceramics
biomaterial
colony stimulating factor 1
interleukin 1
osteoclast differentiation factor
osteoprotegerin
polymer
silicon dioxide
strontium
transcription factor RUNX2
tumor necrosis factor
bone mineralization
bone remodeling
cell activation
cell activity
cell differentiation
cell interaction
cell maturation
cell survival
cytokine release
human
osteoblast
osteoclast
osteoclastogenesis
osteolysis
physical chemistry
protein expression
protein protein interaction
Review
Issue Date: 2018
Citation: Steffi, C, Shi, Z, Kong, C.H, Wang, W (2018). Modulation of osteoclast interactions with orthopaedic biomaterials. Journal of Functional Biomaterials 9 (1) : 18. ScholarBank@NUS Repository. https://doi.org/10.3390/jfb9010018
Abstract: Biomaterial integration in bone depends on bone remodelling at the bone-implant interface. Optimal balance of bone resorption by osteoclasts and bone deposition by osteoblasts is crucial for successful implantation, especially in orthopaedic surgery. Most studies examined osteoblast differentiation on biomaterials, yet few research has been conducted to explore the effect of different orthopaedic implants on osteoclast development. This review covers, in detail, the biology of osteoclasts, in vitro models of osteoclasts, and modulation of osteoclast activity by different implant surfaces, bio-ceramics, and polymers. Studies show that surface topography influence osteoclastogenesis. For instance, metal implants with rough surfaces enhanced osteoclast activity, while smooth surfaces resulted in poor osteoclast differentiation. In addition, surface modification of implants with anti-osteoporotic drug further decreased osteoclast activity. In bioceramics, osteoclast development depended on different chemical compositions. Strontium-incorporated bioceramics decreased osteoclast development, whereas higher concentrations of silica enhanced osteoclast activity. Differences between natural and synthetic polymers also modulated osteoclastogenesis. Physiochemical properties of implants affect osteoclast activity. Hence, understanding osteoclast biology and its response to the natural microarchitecture of bone are indispensable to design suitable implant interfaces and scaffolds, which will stimulate osteoclasts in ways similar to that of native bone. © 2018 by the authors.
Source Title: Journal of Functional Biomaterials
URI: https://scholarbank.nus.edu.sg/handle/10635/175068
ISSN: 20794983
DOI: 10.3390/jfb9010018
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