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Title: Targeted approaches for in situ gut microbiome manipulation
Authors: Lee, H.L 
Shen, H
Hwang, I.Y 
Ling, H 
Yew, W.S 
Lee, Y.S 
Chang, M.W 
Keywords: prebiotic agent
probiotic agent
bacterial colonization
bacterial strain
Bacteroides thetaiotaomicron
Bifidobacterium adolescentis
Caenorhabditis elegans
CRISPR-CAS9 system
Crohn disease
Enterococcus faecalis
Escherichia coli
Faecalibacterium prausnitzii
genetic engineering
genetic manipulation
in vivo study
intestine flora
Lactobacillus rhamnosus
Lactobacillus sakei
Lactococcus lactis
Listeria monocytogenes
measurement precision
Peptoclostridium difficile
Pseudomonas aeruginosa
ulcerative colitis
Vibrio cholerae
Issue Date: 2018
Citation: Lee, H.L, Shen, H, Hwang, I.Y, Ling, H, Yew, W.S, Lee, Y.S, Chang, M.W (2018). Targeted approaches for in situ gut microbiome manipulation. Genes 9 (7) : 351. ScholarBank@NUS Repository.
Abstract: Microbial communities and their collective genomes form the gut microbiome, of which bacteria are the major contributor. Through their secreted metabolites, bacteria interact with the host, influencing human health and physiology. Perturbation of the microbiota and metabolome has been associated with various diseases and metabolic conditions. As knowledge on fundamental host-microbiome interactions and genetic engineering tools becomes readily available, targeted manipulation of the gut microbiome for therapeutic applications gains favourable attention. Manipulation of the gut microbiome can be achieved by altering the microbiota population and composition, or by modifying the functional metabolic activity of the microbiome to promote health and restore the microbiome balance. In this article, we review current works that demonstrate various strategies employed to manipulate the gut microbiome in situ to various degrees of precision. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Genes
ISSN: 20734425
DOI: 10.3390/genes9070351
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