Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-30487-6
Title: IL-1?, IL-6, TNF- ? and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis
Authors: Ng, A
Tam, W.W 
Zhang, M.W 
Ho, C.S
Husain, S.F 
McIntyre, R.S
Ho, R.C 
Keywords: C reactive protein
IL1B protein, human
IL6 protein, human
interleukin 1beta
interleukin 6
protein
TNFAIP1 protein, human
aged
Alzheimer disease
blood
depression
human
inflammation
meta analysis
middle aged
Aged
Alzheimer Disease
C-Reactive Protein
Depression
Depressive Disorder
Humans
Inflammation
Interleukin-1beta
Interleukin-6
Middle Aged
Proteins
Issue Date: 2018
Citation: Ng, A, Tam, W.W, Zhang, M.W, Ho, C.S, Husain, S.F, McIntyre, R.S, Ho, R.C (2018). IL-1?, IL-6, TNF- ? and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis. Scientific Reports 8 (1) : 12050. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-30487-6
Abstract: We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1?), Interleukin-6 (IL-6), Tumor Necrosis Factor-? (TNF- ?) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer’s disease. We searched Pubmed, PsycINFO and Embase, and thirty-four relevant studies (2609 with Depression, 1645 with Alzheimer’s disease and 14363 Controls) were included. Compared with controls, IL-1? (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078–1.206; significant heterogeneity: I2 = 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156–0.598; significant heterogeneity: I2 = 88.75%) were significantly elevated in depression. There was no difference in TNF-? (p = 0.351) and CRP (p = 0.05) between those with depression and controls. Compared with controls, IL-1? (pooled SMD: 1.37, 95% CI: 0.06–2.68, significant heterogeneity: I2 = 96.01%) was significantly elevated in Alzheimer’s disease. There were no differences in IL-6 (p = 0.138), TNF-? (p = 0.451) and CRP (p = 0.07) between elderly with Alzheimer’s disease and controls. After Bonferroni adjustment, only IL-6 remained significantly higher in depression. Elderly with depression have higher IL-6 than controls, while those with Alzheimer’s disease did not have higher peripheral inflammatory markers. © 2018, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175017
ISSN: 20452322
DOI: 10.1038/s41598-018-30487-6
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