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https://doi.org/10.1038/srep22031
Title: | Assessing the causality between blood pressure and retinal vascular caliber through mendelian randomisation | Authors: | Li, L.-J Liao, J Cheung, C.Y.-L Ikram, M.K Shyong, T.E Wong, T.-Y Cheng, C.-Y |
Keywords: | biological marker aged blood pressure ethnic group ethnology Eye Diseases female genetic association study genetic predisposition human male middle aged pathology retina blood vessel risk Singapore statistical model Aged Biomarkers Blood Pressure Ethnic Groups Eye Diseases Female Genetic Association Studies Genetic Predisposition to Disease Humans Male Middle Aged Models, Statistical Retinal Vessels Risk Singapore |
Issue Date: | 2016 | Publisher: | Nature Publishing Group | Citation: | Li, L.-J, Liao, J, Cheung, C.Y.-L, Ikram, M.K, Shyong, T.E, Wong, T.-Y, Cheng, C.-Y (2016). Assessing the causality between blood pressure and retinal vascular caliber through mendelian randomisation. Scientific Reports 6 : 22031. ScholarBank@NUS Repository. https://doi.org/10.1038/srep22031 | Abstract: | We aimed to determine the association between blood pressure (BP) and retinal vascular caliber changes that were free from confounders and reverse causation by using Mendelian randomisation. A total of 6528 participants from a multi-ethnic cohort (Chinese, Malays, and Indians) in Singapore were included in this study. Retinal arteriolar and venular caliber was measured by a semi-automated computer program. Genotyping was done using Illumina 610-quad chips. Meta-analysis of association between BP, and retinal arteriolar and venular caliber across three ethnic groups was performed both in conventional linear regression and Mendelian randomisation framework with a genetic risk score of BP as an instrumental variable. In multiple linear regression models, each 10 mm Hg increase in systolic BP, diastolic BP, and mean arterial BP (MAP) was associated with significant decreases in retinal arteriolar caliber of a 1.4, 3.0, and 2.6 ?m, and significant decreases in retinal venular caliber of a 0.6, 0.7, and 0.9 ?m, respectively. In a Mendelian randomisation model, only associations between DBP and MAP and retinal arteriolar narrowing remained yet its significance was greatly reduced. Our data showed weak evidence of a causal relationship between elevated BP and retinal arteriolar narrowing. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/174991 | ISSN: | 20452322 | DOI: | 10.1038/srep22031 |
Appears in Collections: | Elements Staff Publications |
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