Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep22031
Title: Assessing the causality between blood pressure and retinal vascular caliber through mendelian randomisation
Authors: Li, L.-J 
Liao, J 
Cheung, C.Y.-L
Ikram, M.K 
Shyong, T.E 
Wong, T.-Y 
Cheng, C.-Y 
Keywords: biological marker
aged
blood pressure
ethnic group
ethnology
Eye Diseases
female
genetic association study
genetic predisposition
human
male
middle aged
pathology
retina blood vessel
risk
Singapore
statistical model
Aged
Biomarkers
Blood Pressure
Ethnic Groups
Eye Diseases
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Models, Statistical
Retinal Vessels
Risk
Singapore
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Li, L.-J, Liao, J, Cheung, C.Y.-L, Ikram, M.K, Shyong, T.E, Wong, T.-Y, Cheng, C.-Y (2016). Assessing the causality between blood pressure and retinal vascular caliber through mendelian randomisation. Scientific Reports 6 : 22031. ScholarBank@NUS Repository. https://doi.org/10.1038/srep22031
Abstract: We aimed to determine the association between blood pressure (BP) and retinal vascular caliber changes that were free from confounders and reverse causation by using Mendelian randomisation. A total of 6528 participants from a multi-ethnic cohort (Chinese, Malays, and Indians) in Singapore were included in this study. Retinal arteriolar and venular caliber was measured by a semi-automated computer program. Genotyping was done using Illumina 610-quad chips. Meta-analysis of association between BP, and retinal arteriolar and venular caliber across three ethnic groups was performed both in conventional linear regression and Mendelian randomisation framework with a genetic risk score of BP as an instrumental variable. In multiple linear regression models, each 10 mm Hg increase in systolic BP, diastolic BP, and mean arterial BP (MAP) was associated with significant decreases in retinal arteriolar caliber of a 1.4, 3.0, and 2.6 ?m, and significant decreases in retinal venular caliber of a 0.6, 0.7, and 0.9 ?m, respectively. In a Mendelian randomisation model, only associations between DBP and MAP and retinal arteriolar narrowing remained yet its significance was greatly reduced. Our data showed weak evidence of a causal relationship between elevated BP and retinal arteriolar narrowing.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174991
ISSN: 20452322
DOI: 10.1038/srep22031
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_srep22031.pdf387.08 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

2
checked on Jan 20, 2021

Page view(s)

32
checked on Jan 15, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.