Please use this identifier to cite or link to this item:
https://doi.org/10.1038/ncomms11008
| Title: | Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error | Authors: | Fan Q. Verhoeven V.J.M. Wojciechowski R. Barathi V.A. Hysi P.G. Guggenheim J.A. Hohn R. Vitart V. Khawaja A.P. Yamashiro K. Hosseini S.M. Lehtimaki T. Lu Y. Haller T. Xie J. Delcourt C. Pirastu M. Wedenoja J. Gharahkhani P. Venturini C. Miyake M. Hewitt A.W. Guo X. Mazur J. Huffman J.E. Williams K.M. Polasek O. Campbell H. Rudan I. Vatavuk Z. Wilson J.F. Joshi P.K. McMahon G. St Pourcain B. Evans D.M. Simpson C.L. Schwantes-An T.-H. Igo R.P. Mirshahi A. Cougnard-Gregoire A. Bellenguez C. Blettner M. Raitakari O. Kahonen M. Seppala I. Zeller T. Meitinger T. Ried J.S. Gieger C. Portas L. Van Leeuwen E.M. Amin N. Uitterlinden A.G. Rivadeneira F. Hofman A. Vingerling J.R. Wang Y.X. Wang X. Tai-Hui Boh E. Ikram M.K. Sabanayagam C. Gupta P. Tan V. Zhou L. Ho C.E.H. Lim W. Beuerman R.W. Siantar R. Tai E.-S. Vithana E. Mihailov E. Khor C.-C. Hayward C. Luben R.N. Foster P.J. Klein B.E.K. Klein R. Wong H.-S. Mitchell P. Metspalu A. Aung T. Young T.L. He M. Parssinen O. Van Duijn C.M. Jin Wang J. Williams C. Jonas J.B. Teo Y.-Y. MacKey D.A. Oexle K. Yoshimura N. Paterson A.D. Pfeiffer N. Wong T.-Y. Baird P.N. Stambolian D. Wilson J.E.B. Cheng C.-Y. Hammond C.J. Klaver C.C.W. Saw S.-M. Rahi J.S. Korobelnik J.-F. Kemp J.P. Timpson N.J. Smith G.D. Craig J.E. Burdon K.P. Fogarty R.D. Iyengar S.K. Chew E. Janmahasatian S. Martin N.G. MacGregor S. Xu L. Schache M. Nangia V. Panda-Jonas S. Wright A.F. Fondran J.R. Lass J.H. Feng S. Zhao J.H. Khaw K.-T. Wareham N.J. Rantanen T. Kaprio J. Pang C.P. Chen L.J. Tam P.O. Jhanji V. Young A.L. Doring A. Raffel L.J. Cotch M.-F. Li X., Yip S.P. Yap M.K.H. Biino G. Vaccargiu S. Fossarello M. Fleck B. Yazar S. Tideman J.W.L. Tedja M. Deangelis M.M. Morrison M. Farrer L. Zhou X. Chen W. Mizuki N. Meguro A. Makela K.M. |
Keywords: | ancestry education error analysis eye eye disease gene expression genome genotype-environment interaction meta-analysis polymorphism public health refraction adult AREG gene ARID2 SNAT1 gene Article Asian DIS3L MAP2K1 gene educational status European FAM150B ACP1 gene FBN1 gene GABRR1 gene gene gene expression gene identification gene linkage disequilibrium gene locus genetic association genotype genotype environment interaction human LINC00340 gene major clinical study myopia PDE10A gene phenotype single nucleotide polymorphism SLC14A2 gene Asian continental ancestry group Caucasian environment gene expression profiling genetic predisposition genetics genome-wide association study meta analysis refraction error single nucleotide polymorphism Asia Europe Asian Continental Ancestry Group Educational Status Environment European Continental Ancestry Group Gene Expression Profiling Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Polymorphism, Single Nucleotide Refractive Errors |
Issue Date: | 2016 | Publisher: | Nature Publishing Group | Citation: | Fan Q., Verhoeven V.J.M., Wojciechowski R., Barathi V.A., Hysi P.G., Guggenheim J.A., Hohn R., Vitart V., Khawaja A.P., Yamashiro K., Hosseini S.M., Lehtimaki T., Lu Y., Haller T., Xie J., Delcourt C., Pirastu M., Wedenoja J., Gharahkhani P., Venturini C., Miyake M., Hewitt A.W., Guo X., Mazur J., Huffman J.E., Williams K.M., Polasek O., Campbell H., Rudan I., Vatavuk Z., Wilson J.F., Joshi P.K., McMahon G., St Pourcain B., Evans D.M., Simpson C.L., Schwantes-An T.-H., Igo R.P., Mirshahi A., Cougnard-Gregoire A., Bellenguez C., Blettner M., Raitakari O., Kahonen M., Seppala I., Zeller T., Meitinger T., Ried J.S., Gieger C., Portas L., Van Leeuwen E.M., Amin N., Uitterlinden A.G., Rivadeneira F., Hofman A., Vingerling J.R., Wang Y.X., Wang X., Tai-Hui Boh E., Ikram M.K., Sabanayagam C., Gupta P., Tan V., Zhou L., Ho C.E.H., Lim W., Beuerman R.W., Siantar R., Tai E.-S., Vithana E., Mihailov E., Khor C.-C., Hayward C., Luben R.N., Foster P.J., Klein B.E.K., Klein R., Wong H.-S., Mitchell P., Metspalu A., Aung T., Young T.L., He M., Parssinen O., Van Duijn C.M., Jin Wang J., Williams C., Jonas J.B., Teo Y.-Y., MacKey D.A., Oexle K., Yoshimura N., Paterson A.D., Pfeiffer N., Wong T.-Y., Baird P.N., Stambolian D., Wilson J.E.B., Cheng C.-Y., Hammond C.J., Klaver C.C.W., Saw S.-M., Rahi J.S., Korobelnik J.-F., Kemp J.P., Timpson N.J., Smith G.D., Craig J.E., Burdon K.P., Fogarty R.D., Iyengar S.K., Chew E., Janmahasatian S., Martin N.G., MacGregor S., Xu L., Schache M., Nangia V., Panda-Jonas S., Wright A.F., Fondran J.R., Lass J.H., Feng S., Zhao J.H., Khaw K.-T., Wareham N.J., Rantanen T., Kaprio J., Pang C.P., Chen L.J., Tam P.O., Jhanji V., Young A.L., Doring A., Raffel L.J., Cotch M.-F., Li X., Yip S.P., Yap M.K.H., Biino G., Vaccargiu S., Fossarello M., Fleck B., Yazar S., Tideman J.W.L., Tedja M., Deangelis M.M., Morrison M., Farrer L., Zhou X., Chen W., Mizuki N., Meguro A., Makela K.M. (2016). Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature Communications 7 : 11008. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms11008 | Abstract: | Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia. | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/174980 | ISSN: | 20411723 | DOI: | 10.1038/ncomms11008 |
| Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| 10_1038_ncomms11008.pdf | 767.27 kB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.