Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep26117
Title: Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis - A targeted 'omics study
Authors: Lee, Y.H 
Cui, L
Fang, J 
Chern, B.S.M 
Tan, H.H 
Chan, J.K.Y 
Keywords: biological marker
cytokine
oxylipin
blood
endometriosis
female
human
inflammation
laparoscopy
liquid chromatography
pathology
tandem mass spectrometry
Biomarkers
Chromatography, Liquid
Cytokines
Endometriosis
Female
Humans
Inflammation
Laparoscopy
Oxylipins
Tandem Mass Spectrometry
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Lee, Y.H, Cui, L, Fang, J, Chern, B.S.M, Tan, H.H, Chan, J.K.Y (2016). Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis - A targeted 'omics study. Scientific Reports 6 : 26117. ScholarBank@NUS Repository. https://doi.org/10.1038/srep26117
Abstract: Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial-like tissues at extrauterine sites. Elevation in protein and lipid mediators of inflammation including oxylipins and cytokines within the peritoneum characterize the inflamed pelvic region and may contribute to the survival and growth of displaced endometrial tissues. The presence of a clinically silent but molecularly detectable systemic inflammation in endometriosis has been proposed. Thus, we examined serum oxylipin and immunomodulatory protein levels in 103 women undergoing laparoscopy to evaluate systematically any involvement in systemic pathophysiological inflammation in endometriosis. Oxylipin levels were similar between women with and without endometriosis. Stratification by menstrual phase or severity did not offer any difference. Women with ovarian endometriosis had significantly lower 12-HETE relative to peritoneal endometriosis (-50.7%). Serum oxylipin levels were not associated with pre-operative pain symptoms. Changes to immunomodulatory proteins were minimal, with IL-12(p70), IL-13 and VEGF significantly lower in mild endometriotic women compared to non-endometriotic women (-39%, -54% and -76% respectively). Verification using C-reactive protein as a non-specific marker of inflammation further showed similar levels between groups. The implications of our work suggest pro-inflammatory mediators in the classes studied may have potentially limited value as circulating biomarkers for endometriosis, suggesting of potentially tenuous systemic inflammation in endometriosis.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174963
ISSN: 20452322
DOI: 10.1038/srep26117
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