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Title: Mice lacking Programmed cell death-1 show a role for CD8 + T cells in long-term immunity against blood-stage malaria
Authors: Horne-Debets, J.M
Karunarathne, D.S
Faleiro, R.J
Poh, C.M
Renia, L 
Wykes, M.N
Keywords: Pdcd1 protein, mouse
programmed death 1 receptor
C57BL mouse
CD8+ T lymphocyte
disease model
knockout mouse
Plasmodium chabaudi
CD8-Positive T-Lymphocytes
Disease Models, Animal
Mice, Inbred C57BL
Mice, Knockout
Plasmodium chabaudi
Programmed Cell Death 1 Receptor
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Horne-Debets, J.M, Karunarathne, D.S, Faleiro, R.J, Poh, C.M, Renia, L, Wykes, M.N (2016). Mice lacking Programmed cell death-1 show a role for CD8 + T cells in long-term immunity against blood-stage malaria. Scientific Reports 6 : 26210. ScholarBank@NUS Repository.
Abstract: Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion of programmed cell death-1 (PD-1KO) generate sterile immunity unlike wild type (WT) mice. Here we investigated if the mechanism underlying this defect during acute immunity also impacts on long-term immunity. We infected WT and PD-1KO mice with Pch-malaria and measured protection as well as immune responses against re-infections, 15 or 20 weeks after the original infection had cleared. WT mice showed approximately 1% parasitemia compared to sterile immunity in PD-1KO mice on re-infection. An examination of the mechanisms of immunity behind this long-term protection in PD-1KO mice showed a key role for parasite-specific CD8 + T cells even when CD4 + T cells and B cells responded to re-infection. These studies indicate that long-term CD8 + T cell-meditated protection requires consideration for future malaria vaccine design, as part of a multi-cell type response.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/srep26210
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