Please use this identifier to cite or link to this item: https://doi.org/10.4269/ajtmh.15-0468
Title: Dissecting Japan's dengue outbreak in 2014
Authors: Quam M.B.
Sessions O. 
Kamaraj U.S. 
Rocklöv J.
Wilder-Smith A. 
Keywords: Aedes aegypti
Aedes albopictus
air temperature
Article
autumn
China
circadian rhythm
climate
dengue
Dengue virus 1
epidemic
Fourier transformation
gene sequence
human
incubation time
Indonesia
Japan
mortality rate
multiple sequence alignment
phylogenetic tree
phylogeny
precipitation
seasonal variation
sequence alignment
Singapore
spring
summer
travel
Viet Nam
winter
dengue
season
Dengue
Humans
Japan
Phylogeny
Seasons
Issue Date: 2016
Citation: Quam M.B., Sessions O., Kamaraj U.S., Rocklöv J., Wilder-Smith A. (2016). Dissecting Japan's dengue outbreak in 2014. American Journal of Tropical Medicine and Hygiene 94 (2) : 409-412. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.15-0468
Abstract: Despite Japan's temperate climate, a dengue outbreak occurred in Tokyo for the first time in over 70 years in 2014. We dissected this dengue outbreak based on phylogenetic analysis, travel interconnectivity, and environmental drivers for dengue epidemics. Comparing the available dengue virus 1 (DENV1) E gene sequence from this outbreak with 3,282 unique DENV1 sequences in National Center for Biotechnology Information suggested that the DENV might have been imported from China, Indonesia, Singapore, or Vietnam. With travelers arriving into Japan, Guangzhou (China) may have been the source of DENV introduction, given that Guangzhou also reported a large-scale dengue outbreak in 2014. Coinciding with the 2014 outbreak, Tokyo's climate conditions permitted the amplification of Aedes vectors and the annual peak of vectorial capacity. Given suitable vectors and climate conditions in addition to increasing interconnectivity with endemic areas of Asia, Tokyo's 2014 outbreak did not come as a surprise and may foretell more to come. © 2016 by The American Society of Tropical Medicine and Hygiene.
Source Title: American Journal of Tropical Medicine and Hygiene
URI: https://scholarbank.nus.edu.sg/handle/10635/174666
ISSN: 0002-9637
DOI: 10.4269/ajtmh.15-0468
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