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https://doi.org/10.4269/ajtmh.15-0468
Title: | Dissecting Japan's dengue outbreak in 2014 | Authors: | Quam M.B. Sessions O. Kamaraj U.S. Rocklöv J. Wilder-Smith A. |
Keywords: | Aedes aegypti Aedes albopictus air temperature Article autumn China circadian rhythm climate dengue Dengue virus 1 epidemic Fourier transformation gene sequence human incubation time Indonesia Japan mortality rate multiple sequence alignment phylogenetic tree phylogeny precipitation seasonal variation sequence alignment Singapore spring summer travel Viet Nam winter dengue season Dengue Humans Japan Phylogeny Seasons |
Issue Date: | 2016 | Citation: | Quam M.B., Sessions O., Kamaraj U.S., Rocklöv J., Wilder-Smith A. (2016). Dissecting Japan's dengue outbreak in 2014. American Journal of Tropical Medicine and Hygiene 94 (2) : 409-412. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.15-0468 | Abstract: | Despite Japan's temperate climate, a dengue outbreak occurred in Tokyo for the first time in over 70 years in 2014. We dissected this dengue outbreak based on phylogenetic analysis, travel interconnectivity, and environmental drivers for dengue epidemics. Comparing the available dengue virus 1 (DENV1) E gene sequence from this outbreak with 3,282 unique DENV1 sequences in National Center for Biotechnology Information suggested that the DENV might have been imported from China, Indonesia, Singapore, or Vietnam. With travelers arriving into Japan, Guangzhou (China) may have been the source of DENV introduction, given that Guangzhou also reported a large-scale dengue outbreak in 2014. Coinciding with the 2014 outbreak, Tokyo's climate conditions permitted the amplification of Aedes vectors and the annual peak of vectorial capacity. Given suitable vectors and climate conditions in addition to increasing interconnectivity with endemic areas of Asia, Tokyo's 2014 outbreak did not come as a surprise and may foretell more to come. © 2016 by The American Society of Tropical Medicine and Hygiene. | Source Title: | American Journal of Tropical Medicine and Hygiene | URI: | https://scholarbank.nus.edu.sg/handle/10635/174666 | ISSN: | 0002-9637 | DOI: | 10.4269/ajtmh.15-0468 |
Appears in Collections: | Elements Staff Publications |
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